Quantitative immunochemical fecal occult blood test in health check-up population
10.3760/cma.j.issn.1671-7368.2020.02.005
- VernacularTitle: 体检人群粪便潜血免疫定量检测的结果分析
- Author:
Li ZHAO
1
;
Siyi YUAN
2
;
Xiuchi LI
3
;
Gaiqing RUAN
3
;
Xiaoling HAO
1
;
Fulun LONG
3
;
Tengda XU
4
Author Information
1. Infirmary, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100730, China
2. ICU, Chinese Academy of Medical Science, Peking Union Medical College Hospital, Beijing 100730, China
3. Beijing Aikang Guobin Physical Examination Center, Beijing 100004, China
4. Health Medicine, Chinese Academy of Medical Science, Peking Union Medical College Hospital, Beijing 100730, China
- Publication Type:Journal Article
- Keywords:
Occult blood;
Feces;
Colonic neoplasms;
Healthy examination
- From:
Chinese Journal of General Practitioners
2020;19(2):113-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the application of quantitative immunochemical fecal occult blood test (qFIT) in screening of gastrointestinal diseases for health check-up population.
Methods:Total 19 633 health check-up subjects, who received qFIT in AiKang Guobin Physical Examination Center from January 2018 to June 2019 qFIT, were enroll in the study. The positive rate of subjects who received qFIT were analyzed. Gastrointestinal endoscopy were used to diagnose gastrointestinal lesions. The application of qFIT in screening gastrointestinal diseases, especially colorectal cancer and precancerous lesions was evaluated.
Results:Total 718 (3.66%) subjects were positive for qFIT, among whom 103 (42.3%) underwent gastrointestinal endoscopic examinations. Finally, 33 (42.3%) cases of colon adenoma, 9 (11.5%) cases of peptic ulcer, and 4 (3.1%) cases of colorectal cancer were detected; and other conditions including gastroenteritis and hemorrhoids were were also diagnosed. There were 87 cases whose qFIT were negative performed colon endoscopy, 5 (5.7%) cases of colon adenoma, no colorectal cancer were detected. The mean value of qFIT for colon cancer was higher than that for polyps (3 569±1 085)μg/L vs. (823±106) μg/L, P=0.01]. The detection rate of colon polyps in qFIT positive subjects was higher than that in qFIT negative subjects [32%(33/103) vs.5.7% (5/87)], and the detective rate of colon cancer in qFIT positive subjects was higher than that in qFIT negative subjects [3.9%(4/103) vs.0(0/87)].
Conclusion:Quantitative immunochemical fecal occult blood test can improve the detection rate of colorectal cancer and precancerous lesions in screening of gastrointestinal diseases.
