Progress of immune functions of T helper cells 17 and regulatory T cells and their immunomodulatory effect on non-small cell lung cancer
10.3760/cma.j.issn.1006-9801.2020.01.015
- VernacularTitle: 辅助性T细胞17和调节性T细胞的免疫功能及其对非小细胞肺癌免疫调节作用的研究进展
- Author:
Weijiang MA
1
;
Ping WANG
;
Limin YANG
;
Xin LIU
Author Information
1. Department of Thoracic Surgery, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China
- Publication Type:Review
- Keywords:
Carcinoma, non-small-cell lung;
Regulatory T cells;
T helper cells 17
- From:
Cancer Research and Clinic
2020;32(1):66-69
- CountryChina
- Language:Chinese
-
Abstract:
Under the regulation of various cytokines and different concentrations of cytokines, primary CD4+ T cells can differentiate into different Th subgroups. T helper cells 17 (Th17) and regulatory T cells (Treg cells) are research hotspots in recent years. They play diverse immunomodulatory roles by secreting various target cytokines. Th17 and Treg cells are different from each other but connect with each other, their regulatory mechanism is complex, and they play important roles in non-small cell lung cancer (NSCLC). This paper reviews the progress of the differentiation, the development and the immunological function of Th17 and Treg cells and their immunomodulatory effect on the NSCLC.
