Progress of signaling pathways related to bone destruction after bone metastasis in prostate cancer

VernacularTitle: 前列腺癌骨转移后骨破坏相关信号通路的研究进展
Author: Zhengqin GENG ¹ ; Ling ZHOU ; Jiadai TANG ; Lin XIE
Author Information

1. Department of Internal Medicine 1, Tumor Hospital of Yunnan Province, the Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China
Publication Type:Review
Keywords: Prostate neoplasms; Bone metastasis; Signaling pathway
From: Cancer Research and Clinic 2020;32(1):62-65
CountryChina
Language:Chinese
Abstract: Bone metastasis is one of the common complications of patients with advanced prostate cancer. The treatment of skeletal-related events (SRE) caused by bone metastasis, such as the pain, is not effective, and the prognosis is poor, which seriously affects the quality of life of patients. Therefore, exploring the bone metastasis of prostate cancer is of great significance. At present, the relevant mechanism of bone metastasis is still unclear, and the vicious cycle formed by the interaction between the host microenvironment and prostate cancer cells, might be an important reason, among which, the research on RANK-RANKL signaling pathway is relatively mature. This article reviews the current research status of prostate cancer bone metastasis-related signaling pathways, and describes the regulatory relationships of the same signaling molecules in different signaling pathways.