Progress of Wnt-β-catenin signaling pathway related long non-coding RNA in glioma
10.3760/cma.j.issn.1006-9801.2020.01.013
- VernacularTitle: Wnt-β-catenin信号通路相关长链非编码RNA在胶质瘤中的研究进展
- Author:
Xingguang REN
1
;
Hubin DUAN
;
Youchao XIAO
;
Jiaqi HAO
;
Xin YANG
Author Information
1. Department of Neurosurgery, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Review
- Keywords:
Glioma;
Wnt signaling pathway;
Wnt-β
-catenin signaling pathway;
Long non-coding RNA
- From:
Cancer Research and Clinic
2020;32(1):58-61
- CountryChina
- Language:Chinese
-
Abstract:
Glioma is one of the most common and invasive malignant tumors in the central nervous system. The Wnt-β-catenin signaling pathway is a classical Wnt pathway, which is involved in the occurrence and development of glioma and other tumors. Long non-coding RNA (LncRNA) is a functional RNA molecule without protein coding function, which plays a regulatory role in the occurrence and development of various tumors. Recent studies have shown that LncRNA and Wnt-β-catenin signaling pathways are jointly involved in glioma growth, invasion, migration and other processes, but the complex mechanism has not been thoroughly elaborated. In this paper, the influence of Wnt-β-catenin signaling pathway and its related LncRNA on glioma was reviewed, and the pathogenesis of glioma was deeply understood, so as to find a better way for the diagnosis and treatment of glioma.
