Effects of compound sophora flavescens injection on T helper cells 17, regulatory T cells and the related cytokines in lung cancer patients with cirrhosis
10.3760/cma.j.issn.1006-9801.2020.01.005
- VernacularTitle: 复方苦参注射液对肺癌合并肝硬化患者辅助性T细胞17、调节性T细胞及相关细胞因子的影响
- Author:
Chunfang MA
1
;
Guilan SUN
2
;
Chengyu ZHANG
1
;
Xinpeng LI
1
Author Information
1. Department of Pharmacy, Shouguang People's Hospital of Shandong Province, Shouguang 262700, China
2. Department of Vector Biological Control and Prevention, Shouguang Disease Control and Prevention Center of Shandong Province, Shouguang 262700, China
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Liver cirrhosis;
T helper cells 17;
Regulatory T cells
- From:
Cancer Research and Clinic
2020;32(1):22-26
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of compound sophora flavescens injection on T helper cells 17 (Th17), regulatory T-cells (Treg cells) and the related cytokines in lung cancer patients with cirrhosis.
Methods:A total of 63 patients with early non-small cell lung cancer and cirrhosis in Shouguang People's Hospital of Shandong Province from January 2016 to January 2018 were selected. All patients were scheduled to undergo surgical treatment. The patients were randomly divided into observation group (33 cases) and control group (30 cases) according to the random number table method. The patients in the control group were treated with liver protection, and the patients in the observation group were given compound sophora flavescens on the basis of the control group. After 3 months of treatment, the changes of liver fibrosis index, the levels of Th17 and Treg cells in peripheral blood and the changes of interleukin (IL)-10, IL-17, IL-6, and transforming growth factor (TGF)-β in serum were compared between the two groups.
Results:After treatment, the alanine aminotransferase (ALT) of 15 cases (45.45%) in the observation group were normalized and 6 cases (20.00%) in the control group were normalized. There was a significant difference in ALT normalization rate between the two groups (P < 0.05). The levels of serum laminin (LN) and hyaluronic acid (HA) in the two groups after treatment were lower than those before treatment (all P < 0.05), and the serum LN [(156.74±30.52) ng/ml] and HA [(179.56±25.32) ng/ml] in the observation group after treatment was lower than those in the control group [(210.58±39.42) ng/ml and (203.75±28.79) ng/ml] (t values were 18.236 and 12.184, both P < 0.01). There was no significant difference in the level changes of type Ⅲ procollagen and type Ⅳ collagen between the two groups before and after treatment (all P > 0.05). After treatment, the levels of Th17 and Th17/Treg increased and the level of Treg cells decreased (all P < 0.05). After treatment, the levels of Th17 [(1.32±0.18)%] and Th17/Treg (0.23±0.04) in the observation group were higher than those in the control group [(1.21±0.17)% and 0.20±0.03] (t values were 3.201 and 1.087, both P < 0.01), while the level of Treg cells in the observation group was lower than that in the control group (P < 0.05). After treatment, the serum levels of IL-10, IL-17, IL-6, and TGF-β in the two groups were lower than those before treatment (all P < 0.05), and their levels in the observation group were lower than those in the control group (all P < 0.05).
Conclusion:Compound sophora flavescens injection can improve the liver function and fibrosis index of patients with lung cancer and cirrhosis, and it can regulate the levels of Th17, Treg cells and their related factors, which can be used as a clinical adjuvant.
