Chronic lymphocytic leukemia complicated with multiple myeloma: report of one case and review of literature
10.3760/cma.j.issn.1009-9921.2020.01.011
- VernacularTitle: 慢性淋巴细胞白血病合并多发性骨髓瘤一例并文献复习
- Author:
Xiaoyuan YU
1
;
Xiao DING
1
;
Yingmin LIU
1
;
Hongqiong FAN
1
;
Keju SU
1
;
Yanping YANG
1
;
Qiang GUO
1
;
Fengyan JIN
1
Author Information
1. Department of Hematology, Cancer Center, the First Hospital of Jilin University, Changchun 130021, China
- Publication Type:Journal Article
- Keywords:
Leukemia, lymphocytic, chronic, B-cell;
Multiple myeloma;
Clone cells
- From:
Journal of Leukemia & Lymphoma
2020;29(1):50-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical features, diagnosis, occurrence sequence and clonal origin of chronic lymphocytic leukemia complicated with multiple myeloma.
Methods:The diagnosis and treatment of one patient with multiple myeloma and chronic lymphocytic leukemia who was admitted to the First Hospital of Jilin University in May 2018 was retrospectively analyzed, and the related literatures were reviewed.
Results:This patient began with lumbosacral pain, and he was diagnosed as chronic lymphocytic leukemia complicated with multiple myeloma after bone marrow aspiration, flow cytometry, and blood and urine immunofixation electrophoresis. It is recommended that Rd (lenalidomide + dexamethasone) or MPV (melphalan + prednisone + bortezomib) regimen, but the patient did not receive chemotherapy and died of infectious diarrhea 1 month later.
Conclusions:The occurrence of multiple myeloma and chronic lymphoblastic leukemia may originate from the same clone or different new clone. It is very rare that multiple myeloma and chronic lymphoblastic leukemia can co-occur. Therapeutic options tend to be more aggressive multiple myeloma-based regimen.
