The function of Vav protein in immune system
10.3760/cma.j.issn.1673-4408.2020.01.012
- VernacularTitle: Vav蛋白在免疫系统中的作用
- Author:
Yongchang YANG
1
;
Yubin WU
1
Author Information
1. Department of Pediatric Nephrology and Rheumatology, Shengjing hospital of China Medical University, Shenyang 110004, China
- Publication Type:Review
- Keywords:
Vav;
Guanosine nucleotide exchange factors;
Immune system
- From:
International Journal of Pediatrics
2020;47(1):47-50
- CountryChina
- Language:Chinese
-
Abstract:
Vav-family proteins are guanosine nucleotide exchange factors(GEFs)and one of RhoGEFs family numbers.Vav proteins can influence cell signaling transduction, cytoskeleton recombination and adherence migration in special cells by RhoA, RhoG and Rac-1 pathway.There are 80 kinds of RhoGEFs in mammalian cell.Vav proteins play an important role in hematological system, nervous system, cardiovascular system and immune system.So the function of vav protein in immune system was reviewed in this paper.
