Pathogenesis and management of non-alcoholic fatty liver disease in children
10.3760/cma.j.issn.1673-4408.2020.01.010
- VernacularTitle: 儿童非酒精性脂肪性肝病发病机制及治疗
- Author:
Ting LIU
1
;
Qianqi LIU
1
Author Information
1. Department of Endocrinology, Children′s Hospital of Nanjing Medical University, Nanjing 210008, China
- Publication Type:Review
- Keywords:
Non-alcoholic fatty liver disease;
Obesity;
Children;
Pathogenesis;
Management
- From:
International Journal of Pediatrics
2020;47(1):37-41
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease(NAFLD)refers to a wide spectrum of liver diseases ranging from simple fatty liver to non-alcoholic steatohepatitis, which in turn can evolve into cirrhosis and end stage of liver disease.With the prevalence of childhood obesity worldwide, obesity and its related complications have become important factors endangering children′s health.As a manifestation of metabolic syndrome in the liver, NAFLD has become one of the most common liver diseases in children.Its occurrence and development may be the result of genetic susceptibility, genetic polymorphism, obesity, insulin resistance, cytokines, intestinal flora imbalance and other factors.Current treatments for NAFLD include lifestyle changes, medications, and surgery.This article reviews the epidemic trend, possible pathogenesis and treatment progress of NAFLD in children.
