Research progress of the immune pathogenesis of viral myocarditis
10.3760/cma.j.issn.1673-4408.2020.01.007
- VernacularTitle: 病毒性心肌炎免疫机制研究进展
- Author:
Jiaojiao WAN
1
,
2
,
3
,
4
,
5
;
Qijian YI
1
,
2
,
3
,
4
,
5
Author Information
1. Department of Cardiology, Children′s Hospital of Chongqing Medical University
2. Ministry of Education Key Laboratory of Child Developmental Disorder
3. National Clinical Research Center for Child Health and Disorders
4. China International Science and Technology Cooperation Base of Child Development and Critical Disorders
5. Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China
- Publication Type:Review
- Keywords:
Children;
Viral myocarditis;
Immune mechanism
- From:
International Journal of Pediatrics
2020;47(1):26-29
- CountryChina
- Language:Chinese
-
Abstract:
There is no consensus regarding pathogenesis of viral myocarditis in pediatric patients.It makes a big challenge in clinical diagnosis and treatment.The myocyte injury is wildly recognized to be initiated by viral proliferation and secondary host immune response.It may persist and lead to dilated cardiomyopathy.In serious cases, it could even end up with heart failure, cardiogenic shock and sudden death.A growing number of scholars consider that host immune response is the main cause of severe cardiomyopathy.This review outlines the current progress of immune response in viral myocarditis, aiming to assist the clinical diagnosis and treatment.
