Advances of epigenetic mechanism of tetralogy of Fallot
10.3760/cma.j.issn.1673-4408.2020.01.006
- VernacularTitle: 法洛四联症的表观遗传机制研究进展
- Author:
Guixiang TIAN
1
;
Wei SHENG
1
Author Information
1. Children′s Hospital of Fudan University, Shanghai 201102, China
- Publication Type:Review
- Keywords:
Tetralogy of Fallot;
Epigenetics;
DNA methylation;
MicroRNA;
Histone modification
- From:
International Journal of Pediatrics
2020;47(1):22-25
- CountryChina
- Language:Chinese
-
Abstract:
Epigenetics refers to the heritable changes of gene expression without altering DNA sequence.Epigentic mechanism involves DNA methylation, microRNA, histone modification and so on.Tetralogy of Fallot(TOF)is a common congenital heart disease characterized by ventricular septal defect, pulmonary stenosis, aortic straddling and right ventricular hypertrophy.Many experimental investigations indicate that epigentics plays an important role in the development of the heart.It will be an important research field in the future showing important clinical significance to study the etiology of tetralogy of Fallot.
