Impact of staphylococcus aureus accessory gene regulator system on virulence and antibiotic resistance
10.3760/cma.j.issn.1673-4408.2020.01.001
- VernacularTitle: 金黄色葡萄球菌附属基因调节系统对毒力和耐药性的影响研究进展
- Author:
Yan XU
1
;
Xin YANG
1
;
Suyun QIAN
1
Author Information
1. Pediatric Intensive Care Unit, Beijing Children′s Hospital, Capital Medical University, National Center for Children′s Health, Beijing 100045, China
- Publication Type:Review
- Keywords:
Staphylococcus aureus;
Accessory gene regulator system;
Virulence;
Antibiotic resistance
- From:
International Journal of Pediatrics
2020;47(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Accessory gene regulator(agr)-mediated quorum sensing system plays a crucial role in staphylococcal aureus(S.aureus) pathogenesis.It upregulates secreted virulence factors and downregulates cell surface proteins, thereby influencing invasiveness of S. aureus and cell dispersal from biofilms.S.aureus can be divided into four groups according to the polymorphism in the sequence of agr system and of its corresponding receptor.Auto-inducing peptide(AIP)can activate the agr locus in the same group, but mutually inhibit agr locus from different groups.Recent researches have demonstrated that agr dysfunction is common among S. aureus isolates.Certain agr classes and agr-defective strains have been associated with specific clonal complexes and a variety of diseases, influencing the courses of infections and the antibiotic resistance.In this paper, the effects of different agr types and dysfunctional agr on the virulence, antibiotic resistance and biofilm formation of S. aureus were reviewed.
