Research progress of microRNAs in cardiovascular diseases
10.3760/cma.j.issn.1008-6315.2020.01.021
- VernacularTitle: miRNAs在心血管疾病中的研究进展
- Author:
Gaoshang WANG
1
;
Xuebin ZHAN
;
Yujie ZHAO
Author Information
1. Department of Cardiology, the Seventh People′s Hospital of Zhengzhou, Zhengzhou 450017, China
- Publication Type:Review
- Keywords:
MicroRNAs;
Cardiovascular diseases;
Biomarkers
- From:Clinical Medicine of China
2020;36(1):92-96
- CountryChina
- Language:Chinese
-
Abstract:
Objective:MicroRNAs (miRNAs) are endogenous short stranded RNAs with a length of about 22 NT, which are highly conserved and have no coding function.Mature miRNAs play a role by specifically binding to the 3′untranslated region of the target gene, degrading the mRNA of the gene or hindering its translation at the post transcriptional level, so as to negatively regulate the expression of the target gene and play a biological role.In recent years, the research of miRNAs in cardiovascular diseases is increasingly in-depth.A large number of evidences show that miRNAs play a role in the pathogenesis of many cardiovascular diseases, and will become a potential marker and new treatment target for the diagnosis and prognosis evaluation of cardiovascular diseases.
