Relationship between serum high sensitive C-reactive protein and vascular dysfunction in hemodialysis patients
10.3760/cma.j.issn.1008-6315.2020.01.013
- VernacularTitle: 血清超敏C反应蛋白与血液透析患者血管通路失功间的关系
- Author:
Xin ZHENG
1
;
Shen ZHAN
;
Lihong ZHANG
;
Yuzhu WANG
Author Information
1. Department of Nephrology, Beijing Haidian Hospital, Beijing 100080, China
- Publication Type:Journal Article
- Keywords:
Hemodialysis;
Hypersensitive C-reactive protein;
Vascular access failure;
Total protein
- From:
Clinical Medicine of China
2020;36(1):56-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between high sensitivity C-reactive protein (hs-CRP) and vascular access failure in hemodialysis patients.
Methods:From July 2017 to June 2018, 105 patients with regular hemodialysis were selected from the blood purification center of Beijing Haidian hospital.According to the presence or absence of VAF, the patients were divided into two groups: VAF+ group and VAF - group.The difference of hs CRP level between the two groups was compared.
Results:During the 12-month follow-up, 17 patients had more than one event of vascular failure.The total protein level of VAF+ group was significantly lower than that of VAF-Group((65.61±4.01) g/L and( 68.98±5.66) g/L, P=0.021). The male proportion of VAF+ group was lower than that of VAF-group (29.41% vs 53.41%, P=0.07), but the difference was not statistically significant.There was no significant difference in the annual change level of hs CRP between VAF + group and VAF Group((0.33±5.49) mg/L and(0.57±4.45) mg/L, P=0.840). The level of total protein was the independent protective factor of VAF(OR=0.889, 95%CI 0.797-0.991, P=0.034). The level of hs CRP was not significantly correlated with vascular access events(OR=1.018, 95%CI 0.926-1.119, P=0.713).
Conclusion:There is no correlation between hs CRP and VAF.The exact mechanism of inflammation in intimal hyperplasia needs further study.
