Effect of serum high-sensitivity C-reactive protein and tumor necrosis factor-alpha on prognosis of patients undergoing percutaneous coronary intervention
10.3760/cma.j.issn.1008-6315.2020.01.009
- VernacularTitle: 血清超敏C反应蛋白、肿瘤坏死因子α对经皮冠状动脉介入术患者预后的影响
- Author:
Jiwei FU
1
Author Information
1. Department of Cardiology, Chaoyang Central Hospital, Liaoning Province, Chaoyang 122000, China
- Publication Type:Journal Article
- Keywords:
Acute coronary syndrome;
Percutaneous coronary intervention;
Major adverse cardiovascular events;
High-sensitivity C-reactive protein;
Tumor necrosis factor-alpha
- From:Clinical Medicine of China
2020;36(1):36-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of serum high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-alpha (TNF-α) on the prognosis of patients undergoing percutaneous coronary intervention (PCI).
Methods:From January 2016 to December 2017, 197 patients with acute coronary syndrome (ACS) treated by PCI in our hospital were divided into MACE group (39 cases) and non-MACE group (158 cases) according to whether major adverse cardiovascular events (MACE) occurred after PCI.The serum levels of hs-CRP and TNF-α were compared between the two groups before and 48 hours after PCI.The risk factors of MACE after PCI were analyzed by logistic regression analysis.
Results:One year follow-up results after PCI showed that 39 of 197 ACS patients had MACE after PCI, with an incidence of 19.8% (39/197). There were 39 cases in MACE group and 158 cases in non-MACE group.The serum hs-CRP of the MACE group and the non-MACE group before PCI were (9.70±4.71), (7.50±4.61) mg/L respectively, and 48 hours after PCI were (15.37±5.01), (12.16±4.38) mg/L, respectively.There were significant differences between the two groups (all P<0.01). The serum TNF-α levels before PCI in MACE group and non-MACE group were (33.1±8.9), (25.7±8.0) ng/L, respectively, and 48 hours after PCI were (47.6±8.1), (32.4±7.6) ng/L, respectively.There were significant differences between the two groups (P<0.05 or P<0.01). The results of logistic regression analysis showed that preoperative serum hs CRP and TNF-α were the risk factors of mace in PCI patients (OR (95% CI) was 2.069 (1.715-3.358), 2.825 (1.614-4.372), P value was 0.020 and 0.027, respectively).
Conclusion:The serum levels of hs-CRP and TNF-α are related to the prognosis of patients with PCI.The serum levels of hs-CRP and TNF-α before PCI are risk factors for MACE, which can be used as independent predictors of MACE.
