Efficacy and safety evaluation of magnesium aluminate, lansoprazole, amoxicillin and furazolidone in the treatment of Helicobacter pylori-related gastric ulcer
10.3760/cma.j.issn.1008-6315.2020.01.006
- VernacularTitle: 铝碳酸镁、兰索拉唑、阿莫西林、呋喃唑酮四联疗法治疗幽门螺杆菌相关性胃溃疡的效果及安全性评价
- Author:
Hongwei LIU
1
;
Yujie HUANG
2
;
Jianying YANG
3
;
Guocun PENG
1
;
Shaomin SONG
4
;
Liyun WANG
5
Author Information
1. Department of Gastroenterology, Linxi Hospital, Kailuan General Hospital, Tangshan 063000, China
2. Department of Emergency, Linxi Hospital, Kailuan General Hospitall, Tangshan 063000, China
3. General Ward of Linxi Hospital, Kailuan General Hospital, Tangshan 063000, China
4. Department of Cardiology, Linxi Hospital, Kailuan General Hospital, Tangshan 063000, China
5. Department of Ophthalmology, Linxi Hospital, Kailuan General Hospital, Tangshan 063000, China
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Gastric Ulcer;
Magnesium aluminium carbonate;
Lansoprazole;
Amoxicillin;
Furazolidone
- From:Clinical Medicine of China
2020;36(1):22-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and safety of magnesium aluminium carbonate, lansoprazole, amoxicillin and furazolidone in the treatment of Helicobacter pylori-related gastric ulcer.
Methods:From March 2016 to December 2017, 120 patients with HP related gastric ulcer who met the inclusion criteria were enrolled in the digestive department of Linxi Hospital of Kailuan general hospital.They were divided into observation group and control group with random number table method, 60 cases in each group.The control group was given lansoprazole+ amoxicillin+ furazolidone triple therapy.On this basis, the observation group was added with magnesium aluminum carbonate.The clinical efficacy, clearance rate of Helicobacter pylori, the level of VEGF and EGF in gastric juice were compared between the two groups.
Results:The total clinical effective rate of the observation group was 95.0% (57/60), which was significantly higher than that of the control group (83.3%) (50/60). The difference between the two groups was statistically significant (χ2=4.23, P<0.05). The comprehensive symptom scores of the two groups decreased significantly with the treatment time (observation group: before treatment(9.6±2.2), treatment 2 weeks (5.5±1.5), treatment 4 weeks (4.3±1.2), treatment 6 weeks (3.1±0.8), control group (9.4±2.5), treatment 2 weeks (7.2±1.3), treatment 4 weeks (6.6±1.4), treatment 6 weeks (4.5±1.0)), and observation group syndrome scores There was significant difference between the two groups (Finter-group=23.54, Pinter-group<0.05; Fintra-group=87.62, Pintra-group<0.05; Finteraction=8.47, Pinteraction<0.05). After treatment, VEGF level in gastric juice of the two groups increased significantly after treatment.In the observation group( (429.4±128.5) pg/ml )was significantly higher than that in the control group( (380.3±137.2) pg/ml, t=2.02, P<0.05). The EGF level in gastric juice of the two groups increased significantly after treatment.In the observation group( (658.1±164.0) pg/ml )was significantly higher than that in the control group ((583.5±135.1) pg/ml, t=2.72, P<0.05). The incidence of adverse reactions was 6.7% (4/60) in the observation group and 8.3% (5/60) in the control group.There was no significant difference (χ2=0.12, P>0.05).
Conclusion:The treatment of Helicobacter pylori related gastric ulcer with the combination of aluminum carbonate, lansoprazole, amoxicillin and furazolidone can obviously improve the clinical symptoms and promote the regeneration of ulcer mucosa.
