Clinical effect of knee arthroscopy combined with celecoxib in the treatment of elderly patients with knee osteoarthritis
10.3760/cma.j.issn.1008-6706.2020.01.021
- VernacularTitle: 膝关节镜手术联合塞来昔布治疗老年人膝骨关节炎的临床效果观察
- Author:
Jiandong WENG
1
Author Information
1. Department of Orthopaedics, the Third People's Hospital of Zhuji, Zhuji, Zhejiang 311800, China
- Publication Type:Journal Article
- Keywords:
Osteoarthritis, knee;
Arthroscopy;
Tumor necrosis factor-alpha;
Interleukin-6;
Interleukin-1beta;
Osteoarthritis index;
Celecoxib;
Aged
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(1):86-89
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effect of knee arthroscopy combined with celecoxib in the treatment of elderly patients with knee osteoarthritis.
Methods:According to the random table method, 62 elderly patients with knee osteoarthritis admitted to the Third People's Hospital of Zhuji from October 2016 to October 2018 were divided into control group (31 cases) and observation group (31 cases) according to the digital table.The control group was treated with knee arthroscopic debridement, while the observation group was orally given celecoxib on the basis of the control group.Both two groups were treated for 12 weeks.The curative effect of the two groups was compared, and the changes of WOMAC scale score, knee joint active flexion and extension and inflammatory factors before and after treatment were compared.
Results:The excellent and good rate of the observation group (83.88%) was higher than that of the control group (51.62%) (χ2=7.381, P<0.05). After treatment, the scores of stiffness[(3.56±0.38)points], difficulty in daily activities[(27.38±7.19)points]and pain[(7.94±2.45)points] in the observation group were lower than those in the control group[(5.81±0.76)points, (38.98±5.42)points and (11.36±1.87)points](t=10.182, 14.743, 6.178, all P<0.05). After treatment, the knee joint active flexion and extension in the observation group[(91.24±7.86)°] was higher than that in the control group[(83.42±7.39)°](t=4.036, P<0.05). After treatment, the serum levels of IL-1beta[(16.58±4.25)ng/L], TNF-α[(183.25±24.15)ng/L]and IL-6[(9.98±2.43) ng/L] in the observation group were lower than those in the control group[(26.31±5.47)ng/L, (219.82±29.96)ng/L and (14.52±4.35)ng/L](t=7.821, 5.291, 5.073, all P<0.05).
Conclusion:Knee arthroscopy combined with celecoxib has good clinical effect on elderly patients with knee osteoarthritis.It can improve knee function, alleviate inflammation and improve active knee flexion and extension.
