Comparison of the clinical significance of serum HE4, CA125 and ROMA in the differential diagnosis of ovarian tumor
10.3760/cma.j.issn.1008-6706.2020.01.004
- VernacularTitle: 血清人附睾蛋白4、糖类抗原125和卵巢恶性肿瘤风险模型对卵巢癌鉴别诊断的比较
- Author:
Shengya CAO
1
;
Jia LI
2
;
Hongpeng YANG
1
;
Feng GU
1
;
Feng ZHAO
2
;
Xuguang ZHANG
3
Author Information
1. Department of Clinical Laboratory, Xuzhou Cancer Hospital, Xuzhou, Jiangsu 221005, China
2. Department of Medical Oncology, Xuzhou Cancer Hospital, Xuzhou, Jiangsu 221005, China
3. Department of Radiotherapy, Xuzhou Cancer Hospital, Xuzhou, Jiangsu 221005, China
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
CA-125 antigen;
Human epididymis protein 4;
ROC curve;
Diagnosis, differential;
ROMA
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(1):11-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the clinical significance of human epididymis protein 4(HE4), CA125, ROMA in the differential diagnosis of ovarian cancer.
Methods:From May 2016 to October 2017, 240 patients with ovarian tumor in Xuzhou Cancer Hospital were selected.According to the result of postoperative pathology, the patients were divided into benign ovarian disease group(n=120) and ovarian cancer group(n=120). And 100 healthy women from medical examination center were selected as control group.The electrochemiluminescence (ECLIA) technique was used to assess the serum levels of CA125, HE4, and ROMA was calculated.The clinical significance of HE4, CA125, ROMA in the differential diagnosis of ovarian cancer was analyzed by statistic methods.
Results:The CA125, HE4 concentrations and ROMA in the ovarian cancer group[(370.9±213.2)U/mL, (364.4±227.0)pmpl/L, (80.2±26.1)%]were higher than those in the benign ovarian disease group and the health control group(all P<0.01), there were no statistically significant differences between the benign ovarian disease group and the healthy control group(P=0.356, P=0.321, P=0.292). The sensitivity, specificity, positive and negative predictive values, accuracy of ROMA were higher than those of HE4 and CA125.By using the ROC analysis, the AUC for CA125, HE4, ROMA were 0.832, 0.888, 0.960, respectively, AUC(CA125)
Conclusion:CA125 and HE4 have important value in the diagnosis of ovarian cancer, but the ROMA shows the best diagnostic performance and actual value.
