Expression and significance of hypoxia inducible factor-1α and α-smooth-muscle actin in cervical cancer
10.3760/cma.j.issn.1673-4904.2020.01.004
- VernacularTitle: 乏氧诱导因子-1α和α-平滑肌肌动蛋白在宫颈癌的表达及意义
- Author:
Na YUAN
1
;
Lei WANG
2
;
Qiang XI
1
;
Niandong ZOU
1
;
Xianyu ZHANG
1
Author Information
1. Department of Radiotherapy, the First Affiliated Hospital of Hebei Northern University, Hebei Zhangjiakou 075000, China
2. Department of ICU, the First Affiliated Hospital of Hebei Northern University, Hebei Zhangjiakou 075000, China
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Concurrent chemoradiotherapy;
Hypoxia inducible factor-1 alpha;
Alpha-smooth-muscle actin
- From:
Chinese Journal of Postgraduates of Medicine
2020;43(1):11-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the expression levels of hypoxia inducible factor (HIF)-1α and α-smooth-muscle actin (SMA) in both cervical cancer tissues with concurrent chemoradiotherapy and non-cervical cancer tissues, and assess the clinical significance in cervical cancer.
Methods:The immune-histochemistry was used to detect HIF-1α and α-SMA in 68 cases of cervical cancer tissues and 56 cases of non-cervical cancer tissues (including normal cervical tissues, hysteromyoma and cervical intraepithelial neoplasias) from January 2013 to January 2014 in the First Affiliated Hospital of Hebei Northern University.
Results:The positive expression rates of HIF-1α and α-SMA in cervical cancer tissues and non-cervical cancer tissues were 58.8% (40/68), 39.3% (22/56) and 54.4% (37/68), 35.7% (20/56) respectively; the differences were significant statistically (P<0.05). The expression of HIF-1α was positively correlated with the expression of α-SMA protein in cervical cancer tissues (r = 0.376, P =0.001). The positive expression of HIF-1α was closely related to International Federation of Gynecology and Obstetrics (FIGO) stages (r = 0.371, P = 0.004), lymph node metastasis (r = 0.243, P = 0.039), abdominal aortic parathyroid lymph node metastasis (r = 0.286, P = 0.014) and serum squamous cell carcinoma antigen (SCC-Ag) (r = 0.271, P = 0.020), but it was not correlated with age and tumor size (P>0.05). The positive expression of α-SMA was associated with lymph node metastasis (r = 0.363, P = 0.001), abdominal aortic parathyroid lymph node metastasis (r = 0.271, P = 0.020) and SCC-Ag (r = 0.272, P = 0.020), but it was not correlated with age, FIGO stage and tumor size (P>0.05) . The short-term effect rates of concurrent chemoradiotherapy in cervical cancer tissues with positive and negative expression of HIF-1α and α-SMA were 27.5% (11/40), 21.6% (8/37), and 64.3% (18/28) and 48.4% (15/31), and there were statistical differences (P<0.05). The medial follow-up time of 68 cases was 60 months, and the 5-year survival rate was 52.9% (36/68). The 5-year survival rates of the patients with positive expression of HIF-1α and α-SMA were 42.5% (17/40) and 40.5% (15/31), the 5-year survival rates of the patients with negative expression of HIF-1α and α-SMA were 67.9% (19/28) and 67.7% (21/31), and the differences were statistically significant separately (χ2 = 4.091 and 4.573, P = 0.043 and 0.032).
Conclusions:The elevation of HIF-1α and α-SMA may be used to predict the development and prognosis of cervical cancer with concurrent chemoradiotherapy.
