The assessment of B-type natriuretic peptide be used as a prognositic factor for community-acquired pneumonia
10.3760/cma.j.issn.1008-1372.2020.01.019
- VernacularTitle: B型脑钠肽作为社区获得性肺炎预后指标的价值评价
- Author:
Liang CHEN
1
;
Xiudi HAN
2
;
Xiqian XING
3
;
Xiaoli ZHU
4
Author Information
1. Department of Infectious Disease, Beijing Jishuitan Hospital, Beijing 100096, China
2. Department of Respiratory Medicine, Qingdao Municipal Hospital, Qingdao 266011, China
3. Department of Respiratory Medicine, Yan'an Hospital Affiliated to Kunming Medical University, Kunming 650051, China
4. Department of Occupational Medicine and Toxicology, Beijing Chao-Yang Hospital, Beijing 100043, China
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide, brain;
Community-acquired pneumonia;
Mortality
- From:
Journal of Chinese Physician
2020;22(1):75-79
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the value of B-type natriuretic peptide (BNP) be used as a prognostic factor for community-acquired pneumonia.
Methods:This was a multicenter, retrospective study. Data of patients hospitalized with community-acquired pneumonia during 2014/1/1 to 2015/12/31 from four tertiary hospitals were reviewed, including demographic and clinical features, and outcomes. Univariate analysis and logistic regression analysis were performed to determine risk factors for 30-day mortality. Receiver operating characteristic curves (ROCs) was performed to verify the accuracy of BNP>1 000 pg/ml, CURB-65 score and BNP>1 000 pg/ml+ CURB-65 score (B-CURB65) as 30-day mortality predictors in the study patients.
Results:1 786 patients hospitalized with community-acquired pneumonia (CAP) were entered into the final analysis. The 30-day mortality was 4.7%. Logistic regression analysis confirmed blood BNP>1 000 pg/ml was an independent risk factor associated with 30-day mortality of CAP patients. The area under the curve (AUC) of B-CURB65 was 0.774, which was higher than CURB-65 score (AUC=0.625, P=0.002).
Conclusions:Blood BNP is a valuable biomarker related to the 30-day mortality of CAP patients, which can increase the predicting accuracy of CURB-65 score.
