Analysis of the correlation between IL-23, IL-17and β-cell function in latent autoimmune diabetes in adult patients
10.3760/cma.j.issn.1008-1372.2020.01.017
- VernacularTitle: 血清白介素-23、白介素-17与成人隐匿性自身免疫糖尿病患者β细胞功能的相关性
- Author:
Jie ZHU
1
;
Liping SUN
1
;
Shizhong WANG
2
;
Jie ZHANG
1
;
Meihong WANG
2
;
Fengjing QIAO
2
Author Information
1. Department of Geriatrics, Longkou People′s Hospital, Longkou 256711, China
2. Department of Laboratory, The Traditional Chinese Medicine Hospital of Longkou, Longkou 256711, China
- Publication Type:Journal Article
- Keywords:
Interleukin-23;
Interleukin-17;
Latent autoimmune diabetes in adults;
C-peptide
- From:
Journal of Chinese Physician
2020;22(1):67-70
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine interleukin (IL)-23 and IL-17 level in latent autoimmune diabetes in adult (LADA) patients, and to explore the relationship of IL-23, IL-17and β-cell function in these patients.
Methods:Forty LADA patients from 2011 to 2016 in our hospital were selected as LADA group, and forty participants were as normal control group. Clinical and biochemical data was collected and the level of the IL-23 and IL-17 was measured with the enzyme linked immunosorbent assay (ELISA). The differences in interleukin levels among the two groups were compared. Pearson correlation analysis was used for investigating the relationship between the dependent of statistical significant interleukins and the independent data in the LADA patients, all closely related variables then were included in a stepwise multiple linear regression analysis.
Results:The levels of serum IL-23 , IL-17 and IL-23/IL-17 were significantly higher in LADA group than those in control groups [3.54(2.88~5.24)μg/L vs 1.98(1.62~2.18)μg/L, P<0.05], [22.42(17.71~26.07)ng/L vs 17.97(17.15~20.70)ng/L, P<0.05], (175.79±38.67 vs 105.22±19.08, P<0.01). IL-23 and IL-17 in the LADA group were negatively correlated with fasting C peptide (FCP) (r=-0.42, r=-0.48, P<0.05), and the ratio of IL-23/IL-17 was positively correlated with fasting plasma glucose (FPG) (r=0.44, P=0.00). Stepwise multiple liner regression analysis showed that serum IL-23 and IL-17 level were independently associated with the FCP in LADA group.
Conclusions:IL-23 and IL-17 were possibly important proinflammatory factor in LADA patients, and can provide the new immunodiagnosis markers for LADA.
