Comparison of temporary memory system and brain biochemical metabolites in patients with depressive obsessive-compulsive disorder and simple obsessive-compulsive disorder
10.3760/cma.j.issn.1008-1372.2020.01.013
- VernacularTitle: 抑郁强迫症及单纯强迫症患者暂时记忆系统及脑生化代谢物水平的差异研究
- Author:
Haoran CHEN
1
;
Chongguang LIN
1
;
Langlang CHENG
1
;
Yi XU
2
Author Information
1. Wenzhou Seventh People's Hospital, Psychosomatic Medicine, Wenzhou 325000, China
2. Department of Mental Health, First Affiliated Hospital of Medical College of Zhejiang University, Hangzhou 310003, China
- Publication Type:Journal Article
- Keywords:
Obsessive-compulsive disorder;
Depressive disorder;
Memory, short-term;
N-acetylaspartate;
Choline complex;
Creatine
- From:
Journal of Chinese Physician
2020;22(1):50-53,58
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the difference of temporary memory system and brain biochemical metabolites between patients with depressive obsessive-compulsive disorder and simple obsessive-compulsive disorder.
Methods:From June 2017 to June 2018, 31 patients with simple obsessive-compulsive disorder, 33 patients with depressive obsessive-compulsive disorder and 25 healthy volunteers were selected as subjects. The temporary memory ability of the three groups was tested by n-back, Stoop color association test and digital breadth test. Three brain sublimation metabolites, N-acetylaspartate acid (NAA), choline complex (Cho) and creatine (Cr), were detected by proton magnetic resonance pop (1H-MRS) in bilateral prefrontal white matter, anterior cingulate cortex and anterior cingulate cortex. The ratio of NAA/Cr and Cho/Cr was calculated with Cr as reference material.
Results:The scores of Yale-brown obsessive-compulsive severity scale (Y-BOCS) and Hamilton depression rating scale 24 (HAMD24) in the patients with simple obsessive-compulsive disorder and depression obsessive-compulsive disorder group were significantly higher than those in the healthy control group, and the scores of HAMD24 in the patients with depression obsessive-compulsive disorder group were significantly higher than those in the patients with simple obsessive-compulsive disorder group, with statistically significant difference (P<0.05). The number of correct n-back in the simple obsessive-compulsive group and the depressive obsessive-compulsive group was significantly lower than that in the healthy control group (P<0.05). The digital span test (DST) scores of the patients in the simple obsessive-compulsive disorder group and the depressive obsessive-compulsive disorder group were (14.37±2.96) and (12.39±2.14), which were significantly lower than those in the healthy control group (17.46±3.28) (P<0.05). There was no significant difference in NAA/Cr and Cho/Cr between the three groups (P>0.05). Compared with the healthy control group, the NAA/Cr value of bilateral prefrontal white matter in the simple obsessive-compulsive group and the depression obsessive-compulsive group was significantly lower, and the difference was statistically significant (P<0.05).
Conclusions:Both patients with simple obsessive-compulsive disorder and depressive obsessive-compulsive disorder had speech memory impairment and bilateral prefrontal white matter nerve function decline, while depressive obsessive-compulsive disorder patients also had central executive memory impairment.
