Study on the effect of serum vitamin A and E on children with mycoplasma pneumoniae pneumonia based on propensity score matching
10.3760/cma.j.issn.1008-1372.2020.01.011
- VernacularTitle: 基于倾向性评分匹配法探讨血清维生素A、E对肺炎支原体肺炎患儿的影响
- Author:
Chang XU
1
;
Liyan LUO
;
Niu DING
;
Shijie JIN
;
Shujuan LUO
;
Ting YANG
;
Bichen WU
;
Huaping RAO
Author Information
1. Department of Respiration, Hunan Children′s Hospital, Changsha 410007, China
- Publication Type:Journal Article
- Keywords:
Pneumonia, mycoplasma;
Vitamin A;
Vitamin E;
Child;
Propensity score
- From:
Journal of Chinese Physician
2020;22(1):43-45,49
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between Vitamin A, E and mycoplasma pneumoniae pneumonia in children.
Methods:153 children with mycoplasma pneumoniae pneumonia and 653 health children were selected as cases and controls, respectively. Propensity score matching (PSM) analysis were conducted to reducing confounding bias between groups. Blood samples were collected to test serum levels of vitamin A and E using high performance liquid chromatography (HPLC). Logistic regression was implemented to determine odds ratios (OR) and 95% confidence intervals (CI) for evaluating the association of mycoplasma pneumoniae pneumonia with the serum levels of Vitamin A and E.
Results:After propensity score matching, the study cohort included 153 cases with mycoplasma pneumoniae pneumonia and 306 health children as controls. Before matching, with age and gender adjusted, logistic regression analysis indicated that higher serum levels of Vitamin A and E led to a lower risk of mycoplasma pneumoniae pneumonia (OR=0.075, 95% CI: 0.007-0.815; OR=0.854, 95% CI: 0.792-0.986). After matching, higher serum level of Vitamin E had a significantly lower risk of mycoplasma pneumoniae pneumonia (OR=0.877, 95% CI: 0.810-0.950).
Conclusions:The serum levels of Vitamin A didn't have a statistically significant association with mycoplasma pneumoniae pneumonia. However, we observed an obvious association between Vitamin E and mycoplasma pneumoniae pneumonia. Hence Vitamin E clinical monitoring and supplementation are vital for preventing and treating mycoplasma pneumoniae pneumonia.
