Meta-analysis of the relationship between the polymorphism of ACE and TNF-α gene and the susceptibility of sarcoidosis
10.3760/cma.j.issn.1008-1372.2020.01.010
- VernacularTitle: ACE和TNF-α基因多态性与结节病易感性关系的Meta分析
- Author:
Meiyi LIN
1
;
Pingting YANG
Author Information
1. Department of Rheumatology and Immunology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor-alpha;
Angiotensin-converting enzyme;
Gene polymorphism;
Sarcoidosis;
Meta-analysis
- From:
Journal of Chinese Physician
2020;22(1):36-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the relationship between angiotensin converting enzyme (ACE) and tumor necrosis factors-α (TNF-α) gene polymorphism and sarcoidosis.
Methods:Meta analysis was carried out by retrieving the studies published up to July 2018 to evaluate the relationship between ACE and TNF-α gene polymorphism and sarcoidosis. RevMan 5.3 and Stata 12.0 software were used to analyze the combined OR value and 95% confidence interval (95% CI) by recessive model and dominant model. The stability of the results was judged by ethnic subgroup analysis and sensitivity analysis.
Results:A total of 28 articles and 30 studies met the inclusion criteria, including 7 888 cases, 2 992 cases of sarcoidosis and 4 896 healthy controls. No significant association was found between ACE I/D and sarcoidosis using any model (P>0.05). TNF-α-308A/G was significantly associated with sarcoidosis risk (OR=1.34, 95% CI=1.13-1.58, P=0.0007). Ethnic subgroup analysis showed that the results were significantly different in both the Caucasians (OR=1.36, 95% CI=1.13-1.64, P=0.001) and the Asians (OR=4.88, 95% CI=1.43-16.99, P=0.01).
Conclusions:The meta-analysis identified that AA/AG genotypes at TNF-α-308 were associated with susceptibility to sarcoidosis .However, no significant correlation was found between ACE I/D and the susceptibility of sarcoidosis.
