Association of SNP276 polymorphism in adiponectin gene with essential hypertension in population of Shanxi region with impaired glucose regulation
10.3760/cma.j.issn.1008-1372.2020.01.008
- VernacularTitle: 山西地区糖调节受损患者脂联素基因SNP276多态性与原发性高血压的关系
- Author:
Xuemei FAN
1
;
Guangxia XI
;
Lingxia ZHAO
;
Kun YANG
;
Linlin GAO
Author Information
1. Department of Endocrinology, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Taiyuan 030032 China
- Publication Type:Journal Article
- Keywords:
Adiponectin;
Polymorphism, single nucleotide;
Impaired glucose regulation;
Hypertension
- From:
Journal of Chinese Physician
2020;22(1):29-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the association of single nucleotide polymorphism (SNP)276 in adiponectin gene with essential hypertension in population with impaired glucose regulation in Han people of Shanxi region.
Methods:The study population consisted of 216 Chinese Hans residents with impaired glucose regulation (IGR) in Shanxi province. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was applied to test the adiponectin SNP276G/T polymorphism.
Results:The distributions of genotypes and alleles of SNP276 both displayed significant difference between the IGR complicating norm tension group and the hypertension group (P=0.025, P=0.007). Compared with the TT genotype, the SNP276 non-TT (GT+ GG) genotype was associated with increased risk of complicating with hypertension (OR=3.346, 95% CI: 1.115-8.986, P=0.037), while after age- , sex- and BMI-adjusted, there was no significant difference between the 2 groups (P=0.349).
Conclusions:SNP276 in adipose most abundant gene transcript 1 (APM1) was associated with the susceptibility to be complicating essential hypertension in population with impaired glucose regulation in Han people of Shanxi region.
