Preparation and in vitro imaging of a magnetic heating phasetransition multimodal ultrasound contrast agent
10.3760/cma.j.issn.1004-4477.2020.01.014
- VernacularTitle: 磁热相变型多模态超声造影剂的制备及体外显影研究
- Author:
Yang ZHOU
1
,
2
;
Feng XU
1
,
2
;
Ying LIU
1
;
Ming YE
1
;
Zhigang WANG
3
;
Yuxin ZHAO
1
Author Information
1. Department of Ultrasound, the Second Affiliated Clinical Hospital of Chongqinng Medical University in Chengdu, the Third People′s Hospital of Chengdu City, Chengdu 610031, China
2. Department of Ultrasound, the Forestry Central Hospital of Aba Prefecture, Dujiangyan 611800, China
3. Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, China
- Publication Type:Journal Article
- Keywords:
Magnetic heating;
Phasetransition;
Contrast agent;
Multimodal
- From:
Chinese Journal of Ultrasonography
2020;29(1):77-82
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare a novel magnetic heating phasetransition nanoparticle contrast agent (PFH-HIONS), and to study its performance on enhancing photoacoustic imaging, magnetic resonance imaging and ultrasound imaging after phasetransition by magnetic-thermo in vitro.
Methods:Firstly, the superparamagnetic nano hollow iron spheres (HIONS) were prepared by a one-pot solvothermal method, and then the phasetransition liquid perfluorocarbon (PFH) was loaded on the HIONS by vacuum adsorption to obtain PFH-HIONS. After characterization of the nanoparticles, photoacoustic imaging, magnetic resonance imaging and ultrasound imaging after phasetransition with magnetic-thermo were performed in vitro, and the results were analyzed by a software.
Results:PFH-HIONS was successfully prepared with uniform particle size of (537.3±24.8)nm. PFH-HIONS could apparently enhance photoacoustic imaging and magnetic resonance imaging in vitro. In an alternating magnetic field, it could significantly increase the temperature, which promotes phasetransion of the PFH to produce microbubbles, thereby enhancing ultrasound imaging. Furthermore, as the concentration increased, the imaging intensity was enhanced, and the differences in imaging intensity between different concentration groups were statistically significant (P<0.05).
Conclusions:The PFH-HIONS can enhance the multimodal imaging including ultrasound, photoacoustic and magnetic resonance, and it also has obvious magnetic heating performance. It provides a new and efficient research platform for theranostics based on molecular imaging, therefore it has promising application prospects.
