Influences of cardiovascular risk factors on left ventricular wall motion function in patients treated with epirubicin: a clinical study by layer-specific speckle tracking imaging
10.3760/cma.j.issn.1004-4477.2020.01.005
- VernacularTitle: 斑点追踪分层应变技术评价心血管危险因素对表柔比星化疗乳腺癌患者左室运动功能的影响
- Author:
Ya TAN
1
;
Huilin MA
2
;
Bo HU
1
;
Qianqian LENG
1
;
Qingqiong CAO
1
;
Jiarui LEI
1
;
Ruiqiang GUO
1
Author Information
1. Department of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan 430060, China
2. Department of Function, Wushi Division, Renmin Hospital of Wuhan University, Bole City, Xinjiang Uygur Autonomous Region 833400, China
- Publication Type:Clinical Trail
- Keywords:
Two-dimensional speckle tracking imaging;
Layer-specific imaging;
Breast neoplasms;
Epirubicin;
Myocardial motion;
Cardiovascular risk factors
- From:
Chinese Journal of Ultrasonography
2020;29(1):25-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influences of cardiovascular risk factors on left ventricular wall motion function in patients treated with epirubicin chemotherapy by layer-specific two-dimensional speckle tracking imaging (2D-STI).
Methods:Sixty-four female patients with breast cancer treated with epirubicin and 36 controls from June 2018 to March 2019 in Renmin Hospital of Wuhan University were included. According to the numbers of cardiovascular risk factors, the patients were divided into group A (without cardiovascular risk factors, 31 cases), group B (single cardiovascular risk factor, 20 cases), and group C (multiple cardiovascular risk factors, 13 cases). All patients underwent echocardiography before and after epirubicin respectively. Global longitudinal strain, circumferential strain, radial strain (GLS, GCS, GRS), endocardial and epicardial layers of GLS and GCS (endoGLS, epiGLS, endoGCS, epiGCS) were obtained by EchoPAC software analysis. The differences of GLS, EndoGLS, EpiGLS, GCS, EndoGCS, EpiGCS and GRS before and after chemotheraphy were calculated as ΔGLS, ΔEndoGLS, ΔEpiGLS, ΔGCS, ΔEndoGCS, ΔEpiGCS and ΔGRS.
Results:Compared with before chemotherapy, GLS, EndoGLS, EpiGLS, GCS, EndoGCS, EpiGCS and GRS were significantly reduced in group A, B and C after chemotherapy (all P<0.05). ΔEndoGLS and ΔEndoGCS showed an increasing trend in groups A, B and C, with statistical significance (all P<0.05). Correlation analysis showed that after chemotherapy with epirubicin, the numbers of cardiovascular risk factors were significantly correlated with strain parameters, and the correlation coefficient of EndoGLS was relatively higher (r=-0.582, P<0.001).
Conclusions:Layer-specific imaging can reliably detect the influences of cardiovascular risk factors on the left ventricular wall motion function in breast cancer patients treated with epirubicin. Parameters reflecting the endocardial longitudinal systolic function are sensitive indicators for the early detectin of myocardial damage and toxicity by epirubicin in patients with multiple cardiovascular risk factors.
