Correlation between three-dimensional speckle tracking echocardiography combined with cardiac magnetic resonance imaging-late gadolinium enchancemet on left ventricular global systolic function and myocardial fibrosis in adult hypertrophic cardiomyopathy
10.3760/cma.j.issn.1004-4477.2020.01.002
- VernacularTitle: 超声三维斑点追踪成像联合心脏磁共振成像－钆延迟增强序列对成人肥厚型心肌病左室整体收缩功能与心肌纤维化的关联性研究
- Author:
Lisha NA
1
;
Lei LIU
2
;
Li ZHU
3
;
Xiaochun ZHANG
3
Author Information
1. Department of Echocardiography, Division of Cardiac Center Functional Examination, General Hospital of Ningxia Medical University, Yinchuan 750004, China
2. Department of Ultrasound Diagnosis, Xianyang Central Hospital, Xianyang 712000, China
3. Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China
- Publication Type:Clinical Trail
- Keywords:
Echocardiography;
Three-dimensional speckle tracking imaging;
Cardiomyopathy, hypertrophic;
Cardiac magnetic resonance imaging;
Ventricular function, left;
Myocardial fibrosis
- From:Chinese Journal of Ultrasonography
2020;29(1):6-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the left ventricular global systolic function and myocardial fibrosis in adult hypertrophic cardiomyopathy (HCM) patients by three-dimensional speckle tracking echocardiography(3D-STE) combined with cardiac magnetic resonance imaging-late gadolinium enchancemet (CMRI-LGE) sequence, and to explore the association between left ventricular global systolic function and myocardial fibrosis.
Methods:Thirty patients with HCM(HCM group) and 33 healthy controls(control group) were enrolled in the study. All patients underwent conventional two-dimensional echocardiography (2DE), tissue Doppler imaging (TDI), and 3D-STE. The following parameters were acquired and compared between the groups: interventricular septal end-diastolic thickness (IVSD), left ventricular posterior wall end-diastolic thickness (LVPWD), left ventricular mass(LVM), left ventricular mass index (LVMI), left atrial volume (LAV), and left ventricular end-systolic volume(LVESV), left ventricular end-diastolic volume (LVEDV), left ventricular outflow tract pressure gradient (LVOT-PG), left ventricular outflow tract velocity time integral (LVOT-VTI), isovolumic relaxation time (IVRT), global strain (GS), global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS). And 28 patients who met the CMRI indications underwent CMRI-LGE to obtain the LVM, and the correlation and consistency of LVM results obtained from CMRI and 3D-STE were performed.According to LGE results, HCM patients were divided into LGE(+ ) group and LGE (-) group, the differences of GLS, GRS and GCS between the two groups were analyzed.
Results:①Compared with the control group, IVSD, LVPWD, LVMI, LAV, LVOT-PG, LVOT-VTI and IVRT were significantly increased in the HCM group (all P<0.05); ②There was no significant difference in GS between the two groups(P>0.05), while GLS and GRS decreased and GCS increased significantly in HCM group (P<0.05); ③The correlation between 3D-STE and CMRI in measuring measured LVM in HCM patients was good, and the results showed good concordance(r=0.807, P<0.01). ④GLS in LGE(+ ) group was lower than in LGE(-) group(P=0.004), but there was no significant difference in GCS and GRS between the two groups(P=0.597, 0.534).
Conclusions:①3D-STE can detect the early damage of left ventricular global systolic function in patients with HCM; ②3D-STE combined with CMRI-LGE technology can provide an important imaging reference for the evaluation of the relationship between left ventricular global systolic function and myocardial fibrosis in patients with HCM.
