Mean corpuscular volume ≤100 fl was an independent prognostic factor in patients with myelodysplastic syndrome and bone marrow blast<5 percent

Zhongxun Shi; Tiejun Qin; Zefeng XU; Huijun Huang; Bing LI; Shiqiang QU; Naibo HU; Lijuan Pan; Dan Liu; Ya’nan Cai; Yudi Zhang; Zhijian Xiao

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Mean corpuscular volume ≤100 fl was an independent prognostic factor in patients with myelodysplastic syndrome and bone marrow blast<5 percent

VernacularTitle: 平均红细胞体积≤100 fl是骨髓原始细胞<5%骨髓增生异常综合征患者的独立预后因素
Author: Zhongxun SHI ¹ ; Tiejun QIN ¹ ; Zefeng XU ¹ ; Huijun HUANG ¹ ; Bing LI ¹ ; Shiqiang QU ¹ ; Naibo HU ¹ ; Lijuan PAN ¹ ; Dan LIU ¹ ; Ya’nan CAI ¹ ; Yudi ZHANG ¹ ; Zhijian XIAO ¹
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1. Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, the State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin 300020, China
Publication Type:Journal Article
Keywords: Myelodysplastic syndrome; Mean corpuscular volume; Gene mutation; Prognosis
From: Chinese Journal of Hematology 2020;41(1):28-33
CountryChina
Language:Chinese
Abstract: Objective:To explore the prognostic effects of mean corpuscular volume (MCV) in patients with myelodysplastic syndromes (MDS) .
Methods:321 newly diagnosed, untransfused primary MDS patients who administered from December 2009 to December 2017 were enrolled. The association of MCV with prognosis and several clinical features and genetic mutations were analyzed.
Results:Patients were divided into MCV≤100 fl (n=148) and MCV>100 fl (n=173) cohorts. Median overall survival of patients with MCV≤100 fl was shorter than their counterparts (27 months vs 72 months, P<0.001) . In subgroup analysis, MCV≤100 fl patients had worse survivals in bone marrow blast <5% cohort (34 months vs not reached, P=0.002) , but not so in ≥5 % cohort (17 months vs 20 months, P=0.078) . MCV≤100 fl was still an independent adverse variable (HR=1.890, 95%CI 1.007-3.548, P=0.048) after adjusting for clinical and laboratory variables and mutation topography in bone marrow blasts<5% cohort. In bone marrow blasts<5% cohort, patients with MCV≤100 fl had higher hemoglobin levels [90 (42-153) g/L vs 78.5 (28-146) g/L, P=0.015].The proportions of Revised International Prognostic Scoring System (IPSS-R) high/very high risks and poor/very poor IPSS-R karyotypes were higher in MCV≤100 fl cohort (28.8% vs 10.8%, P=0.003; 24.7% vs 12.9%, P=0.049) . MCV≤100 fl cohort had more genetic mutations than those with MCV>100 fl though without significance (0.988 vs 0.769, P=0.064) . Mutated SF3B1 was less frequently in MCV≤100 fl cohort (4.7% vs 15.4%, P=0.018) .
Conclusion:MCV≤100 fl was an independent adverse variable after adjusting for clinical and laboratory variables and mutation topography in MDS patients with bone marrow blasts<5%.