Value of detection of extracellular vesicles in the diagnosis of nonalcoholic fatty liver disease
10.3760/cma.j.issn.1007-3418.2020.01.022
- VernacularTitle: 细胞外囊泡的检测及其在非酒精性脂肪性肝病诊断中的价值
- Author:
Weiyun JIANG
1
;
Yunhao XUN
2
Author Information
1. Zhejiang Chinese Medical University, Hangzhou 310053, China
2. Xixi Hospital of Hangzhou, Hangzhou 310023, China
- Publication Type:Review
- Keywords:
Fatty liver, non-alcoholic;
Exosomes;
Biological markers;
Extracellular vesicles
- From:
Chinese Journal of Hepatology
2020;28(1):92-96
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular vesicles (EVs) are small bilayer lipid membrane vesicles that can be released by most cell types and detected in most body fluids. EVs exert key functions for intercellular communication via transferring their bioactive cargos to recipient cells or activating signaling pathways in target cells, and hence participate in the variety of diseases including the occurrence and development of liver diseases. In recent years, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased. Currently there is no reliable method except invasive liver biopsy for the diagnosis of liver inflammation or fibrosis staging. Therefore, the search for the corresponding markers of noninvasive circulation continues to be active, and extracellular vesicles are one of the most concerned. To this end, we reviewed current knowledge about the physical characteristics, biological components, and isolation methods of extracellular vesicles, and introduced the concept of using circulating cell-derived vesicles as a new diagnostic marker for nonalcoholic fatty liver disease.
