Hepatocellular carcinoma-derived exosomal miRNA expression and its clinical value
10.3760/cma.j.issn.1007-3418.2020.01.020
- VernacularTitle: 肝癌外泌体源性miRNA表达及其临床价值
- Author:
Mengna WU
1
;
Jianying SUN
1
;
Min YAO
2
;
Dengfu YAO
1
Author Information
1. Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China
2. Department of Immunology, Medical School of Nantong University, Nantong 226001, China
- Publication Type:Review
- Keywords:
Carcinoma, hepatocellular;
Diagnosis;
Target treatment;
Exosomes;
MicroRNA
- From:
Chinese Journal of Hepatology
2020;28(1):83-86
- CountryChina
- Language:Chinese
-
Abstract:
The early diagnosis and effective treatment of hepatocellular carcinoma (HCC) still remains a difficult problem that plagues the medical community. Exosomes are microvesicles with a diameter of 40~100 nm, and contains proteins, lipids and nucleic acids (mRNAs, lncRNAs, circRNAs, and microRNAs). They serve as an information exchange carrier, and play an important role in regulating and controlling the biomolecular function to maintain the stability of the intracellular environment. The function of exosomes in HCC includes intercellular communication, neoangiogenesis, cancer cell metastasis and multidrug resistance, which mediates the transformation of microRNAs (miRNA) and regulate the microenvironment of tumor progression, and then affect the pathophysiological behavior of cancer cells. Exosome-derived miRNA can be used for HCC monitoring or potential specific markers of early diagnosis. In addition, with the development and application prospects it could be a therapeutic goal for HCC. This paper summarizes the recent progress in the study of HCC-derived exosomal miRNA.
