Meta-analysis on effectiveness of live attenuated influenza vaccine against seasonal influenza in children
10.3760/cma.j.issn.0254-6450.2020.01.019
- VernacularTitle: 流感减毒活疫苗预防儿童季节性流感保护效果的Meta分析
- Author:
Yanyang TAO
1
;
Pengfei JIN
2
;
Fengcai ZHU
1
,
3
Author Information
1. School of Public Health, Southeast University, Nanjing 210009, China
2. Department of Vaccine Clinical Evaluation, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China
3. Key Laboratory of Enteric Pathogenic Microbiology of National Health Commission, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China
- Publication Type:Review
- Keywords:
Live attenuated influenza vaccine;
Children;
Seasonal influenza;
Vaccine effectiveness;
Meta-analysis
- From:
Chinese Journal of Epidemiology
2020;41(1):103-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effectiveness of live attenuated influenza vaccine (LAIV) in the prevention of seasonal influenza in children aged 2-17 years.
Methods:Literature retrieval of case-control studies on the effectiveness of LAIV against seasonal influenza in children published from January 2003 to November 2018 was conducted through Web of Science, PubMed, and ScienceDirect databases. The Stata 13.1 software was used for Meta-analysis.
Results:A total of 14 studies were included in this study, and all were test-negative design (TND) studies. Our Meta-analysis showed that the effectiveness of LAIV in children was 49% (95%CI: 40%-57%). Subgroup analysis found that the protection rate of LAIV was 35% against influenza A (H1N1) pdm09 (95%CI: 5%-56%), 35% against influenza A (H3N2) (95%CI: 21%-46%), and 71% against influenza B (95%CI: 55%-82%). The protection rates of trivalent LAIV and quadrivalent LAIV in children were 56% (95%CI: 48%-63%) and 44% (95%CI: 27%-57%), respectively. The protection rates of LAIV in Europe and North America were 65% (95%CI: 47%-77%) and 46% (95%CI: 36%-55%), respectively.
Conclusion:LAIV has a certain preventive effect on seasonal influenza in children aged 2-17 years.
