Effects of estimated glomerular filtration rate on all-cause mortality in the elderly aged 65 years and older in 8 longevity areas in China

Qing Chen; Feng Zhao; Qingmei Huang; Yuebin Lyu; Wenfang Zhong; Jinhui Zhou; Zhihao LI; Yingli QU; Ling Liu; Yingchun Liu; Jiaonan Wang; Zhaojin Cao; Xianbo WU; Xiaoming Shi; Chen Mao

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Effects of estimated glomerular filtration rate on all-cause mortality in the elderly aged 65 years and older in 8 longevity areas in China

VernacularTitle: 中国8个长寿地区65岁及以上老年人肾小球滤过率对全因死亡风险的影响
Author: Qing CHEN ¹ ; Feng ZHAO ² ; Qingmei HUANG ¹ ; Yuebin LYU ² ; Wenfang ZHONG ¹ ; Jinhui ZHOU ² ; Zhihao LI ¹ ; Yingli QU ² ; Ling LIU ² ; Yingchun LIU ² ; Jiaonan WANG ² ; Zhaojin CAO ² ; Xianbo WU ¹ ; Xiaoming SHI ² ; Chen MAO ¹
Author Information

1. Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China
2. National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China
Publication Type:Journal Article
Keywords: Glomerular filtration rate; All-cause mortality; Elderly
From:Chinese Journal of Epidemiology 2020;41(1):36-41
CountryChina
Language:Chinese
Abstract: Objective:To investigate the association between estimated glomerular filtration rate (eGFR) and all-cause mortality in the elderly aged 65 years and older in longevity areas in China.
Methods:Data used in this study were obtained from Healthy Aging and Biomarkers Cohort Study, a sub-cohort of the Chinese Longitudinal Healthy Longevity Survey, 1 802 elderly adults were collected in the study during 2012-2017/2018. In this study, the elderly were classified into 4 groups, moderate-to-severe group [<45 ml·min^-1·(1.73 m²)^-1], mild-to-moderate group [45- ml·min^-1·(1.73 m²)^-1], mild group [60- ml·min^-1·(1.73 m²)^-1] and normal group [≥90 ml·min^-1·(1.73 m²)^-1] according to their eGFR levels.
Results:After 6 years of follow-up, 852 participants died, with a mortality rate of 47.3%. Multivariate Cox regression analysis showed that the levels of eGFR were negatively correlated with all-cause mortality risk in the elderly (the HR of elderly was 0.993 and the 95%CI was 0.989-0.997 for every unit of eGFR increased, P=0.001), while compared with the group with normal eGFR, the HRs (95%CI) of the elderly in the moderate-to-severe group, mild-to-moderate group, and mild group were 1.690 (1.224-2.332, P=0.001), 1.312 (0.978-1.758, P=0.070), 1.349 (1.047-1.737, P=0.020) respectively [trend test P<0.001].
Conclusion:The decrease in eGFR was associated with higher mortality risk among the elderly in longevity areas in China.