Progress in diagnosis and treatment of DNA methylation and pulmonary fibrosis
10.3760/cma.j.issn.1009-9158.2020.01.011
- VernacularTitle: DNA甲基化与肺纤维化的诊治研究进展
- Author:
Zheyi XIANG
1
;
Min HU
Author Information
1. Laboratory of Clinical Medicine, the Second Xiangya Hospital, Central South University, Changsha410011, China
- Publication Type:Review
- Keywords:
DNA methylation;
Pulmonary fibrosis;
Epigenetics
- From:
Chinese Journal of Laboratory Medicine
2020;43(1):91-95
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary fibrosis is the late stage of many lung diseases. It′s a pathological process with excessive deposition of extracellular matrix, tissue scar formation and lung tissue remodeling. Recently, DNA methylation has been demonstrated to involve in organ fibrosis, includingpulmonary, liver, renal fibrosis and so on. DNA methylation plays an important role in clinical diagnosis and treatment. This article reviews the role of DNA methylation in the development of pulmonary fibrosis and discusses thepathogenic mechanism of pulmonary fibrosis and new anti-fibrotic strategy.
