The research progress of animal models of microtia
10.3760/cma.j.issn.1009-4598.2020.01.020
- VernacularTitle: 先天性小耳畸形动物模型及研究进展
- Author:
Meng LU
1
;
Lin LIN
;
Haiyue JIANG
Author Information
1. Department of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, Chin
- Publication Type:Review
- Keywords:
Microtia;
Animal model;
Genetic engineering
- From:
Chinese Journal of Plastic Surgery
2020;36(1):88-93
- CountryChina
- Language:Chinese
-
Abstract:
IIn recent years, an increasing trend of the birth prevalence of anotia/microtia is observed in China, contributed by changes of social environment and lifestyle. There seems to be no major breakthroughs in exact pathogenesis of microtia, though the research results related to molecular genetics unceasingly appear. Animal studies have important implications for exploring the pathophysiologic mechanism of microtia. In this review, we focused on the types and modeling approaches of animal models, as well as the advantages and disadvantages respectively. We believe that this review will provide references for researchers to select and establish appropriate animal models.
