Multicentric clinical study of clinical phenotypic analysis of microtia
10.3760/cma.j.issn.1009-4598.2020.01.003
- VernacularTitle: 先天性小耳畸形及其伴发畸形多中心临床研究
- Author:
Liu LIU
1
;
Xuelian ZHAO
2
;
Haitao WANG
3
;
Gaofeng LI
4
;
Zhengyong LI
5
;
Bo PAN
6
;
Lei YANG
1
Author Information
1. Department of Plastic Surgery, Third Hospital of Hebei Medical University , Shijiazhuang 050051, China
2. Department of Plastic Surgery, Second Hospital of Hebei Medical University , Shijiazhuang 050000, China
3. Department of Plastic Surgery, Weihai Municipal Hospital , Weihai 264200, China
4. Department of Plastic Surgery , Hunan Provincial People′s Hospital , Changsha 410005, China
5. Department of Plastic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China
6. Seventh Department of Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100144, China
- Publication Type:Clinical Trail
- Keywords:
Congenital microtia;
Associated malformations;
Multi-center clinical study
- From:
Chinese Journal of Plastic Surgery
2020;36(1):13-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study collected and analyzed data from patients with microtia in multiple clinical centers to obtain the incidence characteristics of microtia in Chinese.
Methods:Data from 746 patients with microtia were collected from six hospitals, including theThird Hospital of Hebei Medical University, Hunan Provincial People′s Hospital, the Second Hospital of Hebei Medical University, Weihai Municipal Hospital, West China Hospital Sichuan University, Plastic Surgery Hospital, Chinese Academy of Medical Sciences from January 2016 to December 2017. These data included the results of physical examination and the results of auxiliary examination such as electrocardiogram, chest CT, and abdominal ultrasound. Then, the accompanying malformations of the microtia were statistically analyzed and discussed. Data were entered and processed using SPSS 19.0 statistical software. The relationship between microtia deformities and associated malformations was analyzed by Pearson χ2 test. P<0.05 was considered statistically significant.
Results:A total of 746 patients with microtia were included, including 513 males and 233 females, aged 5-27 years old. There were 678 cases of unilateral microtia, 68 cases of bilateral microtia; 128 cases of Ⅰ degree, 564 cases of Ⅱ degree, and 54 cases of Ⅲ degree. In addition, 336 cases (45%) were associated with dysplasia of other systems. Detected anomalies were 321 cases of the ear, face, and neck, 261 cases of musculoskeletal system and 76 cases of cardiovascular system, 30 cases of anomalies of the urogenital system, eye, 27 cases of respiratory system, 7 cases of central nervous system, 5 case of digestive system and 1case of diaphragmatic hernia. The proportion of male and female with microtia was 47.0% (241/513) and 40.8% (95/233), respectively, and there was no significant difference in between (χ2=2.493, P=0.114); The composition ratios of unilateral and bilateral associated malformations were 45.7% (310/678) and 38.2% (26/68 ), and there was no significant difference in between (χ2=1.400, P=0.237); The composition ratios of Ⅰ, Ⅱ, Ⅲ degree-associated malformations were 39.8% (51/128), 42.6% (240/564), and 83.3% (45/54), and the difference was statistically significant (χ2= 34.794, P<0.001).
Conclusions:Microtia has significant clinical heterogeneity with a higher proportion of associated malformations. A higher incidence of associated deformities in patients with severe microtia was observed. Systematic examination is required, which will be helpful to clinical therapy and etiology analysis.
