Progress of pulmonary artery denervation in treatment of pulmonary arterial hypertension
10.3760/cma.j.issn.2095-428X.2020.01.003
- VernacularTitle: 肺动脉去神经治疗肺动脉高压研究进展
- Author:
Silin PAN
1
;
Gang LUO
Author Information
1. Heart Center, Qingdao Women and Children′s Hospital, Qingdao 266034, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
Pulmonary arterial hypertension;
Pulmonary artery denervation;
Autonomic nerve;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(1):6-9
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary artery denervation (PADN) can block local sympathetic nerve of pulmonary artery, reduce the hemodynamic parameters of pulmonary arterial hypertension(PAH), attenuate pulmonary vascular remodeling, right ventricular hypertrophy and fibrosis, thus improving cardiac function.Early basic experiment has determined the position of sympathetic nerve of pulmonary artery in pulmonary endarterium and confirmed the safety and effectiveness of PADN in the animal model of PAH.PADN may play a role by inhibiting execssive activation of the sympathetic nervous system and renin-angiotension-aldosterone system.PADN has been applied to adult clinical research, and has achieved a good clinical effect.On this basis, the possibility of applying PADN to children′s PAH is being explored preliminarily.
