Epigenetic mechanisms of bronchopulmonary dysplasia: a review
10.3760/cma.j.issn.1007-9408.2020.01.011
- VernacularTitle: 支气管肺发育不良的表观遗传学机制研究进展
- Author:
Peijuan CHEN
1
;
Zhiting WAN
2
;
Baohuan CAI
1
;
Wenbin LI
1
Author Information
1. Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2. Department of Pediatrics, Xianning Central Hospital, First Affiliated Hospital of Hubei University of Science and Technology, Xianning 437100, China
- Publication Type:Review
- Keywords:
Bronchopulmonary dysplasia;
Epigenomics;
Histone code;
RNA, untranslated;
DNA methylation
- From:
Chinese Journal of Perinatal Medicine
2020;23(1):56-60
- CountryChina
- Language:Chinese
-
Abstract:
Bronchopulmonary dysplasia (BPD) is a common chronic respiratory complication in preterm infants without fully understand the mechanism or effective treatment, which could significantly affect the survival rate and prognosis of these infants. Studies have confirmed that epigenetic mechanisms, including histone modification, non-coding RNA and DNA methylation may play an essential role in the onset and development of BPD. And most related epigenetic changes are reversible, which might serve as a potential target for BPD treatment. Therefore, further studies on epigenetics will shed light on a better understanding of the pathogenesis, prevention, and treatment of BPD.
