Research progress in hemolytic disease in fetuses and newborns: a review
10.3760/cma.j.issn.1007-9408.2020.01.009
- VernacularTitle: 胎儿及新生儿免疫溶血性疾病研究进展
- Author:
Yuanjun WU
1
;
Fubing YU
2
;
Yong YANG
3
Author Information
1. Department of Blood Transfusion, Dongguan Maternal and Child Health Care Hospital, Dongguan 523120, China
2. Department of Obstetrics, Dongguan Maternal and Child Health Care Hospital, Dongguan 523120, China
3. Department of Neonatology, Dongguan Maternal and Child Health Care Hospital, Dongguan 523120, China
- Publication Type:Review
- Keywords:
Erythroblastosis, fetal;
Rh Isoimmunization;
Immunoglobulin G;
Isoantibodies
- From:
Chinese Journal of Perinatal Medicine
2020;23(1):44-51
- CountryChina
- Language:Chinese
-
Abstract:
Hemolytic disease in fetuses and newborns (HDFN) is a common perinatal condition caused by the destruction of erythrocytes of neonates or fetuses by maternal IgG antibodies. Fetal or neonatal hemolysis is HDFN's primary pathological process resulting in anemia and neonatal jaundice. This review summarized recent progress in the pathophysiology of HDFN, the clinical correlation between anti-erythrocyte alloantibodies and HDFN, laboratory tests for alloimmunization in pregnancy, clinical evaluation of high-risk cases of HDFN, and treatment and prevention of HDFN at home and abroad.
