Emphasis on biomaterial research in bone defect repair of osteoporotic fracture
10.3760/cma.j.issn.1001-8050.2020.01.004
- VernacularTitle: 重视对骨质疏松性骨折骨缺损修复材料的研究
- Author:
Honglei WANG
1
;
Xue QU
1
;
Changsheng LIU
1
Author Information
1. Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China
- Publication Type:Journal Article
- Keywords:
Osteoporotic fractures;
Tissue scaffolds;
Bone regeneration
- From:
Chinese Journal of Trauma
2020;36(1):9-13
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis results in decreased bone mass, impaired bone strength and bone microstructure, and thus can easily cause bone fracture. Osteoporosis is one of the common diseases troubling the aging people. Due to the decreased activity of osteoblasts as well as impaired osteogenic differentiation of mesenchymal stem cells, the repair of bone defects accompanied with osteoporosis is very limited. It is a promising way to enhance the healing effect of such bone defect through implanting biomaterials with improved physical and chemical properties as well as elevated bioactivities, since it can mediate the activities of osteogenesis related cells in situ. The author summarizes the popular methods for the modification of biomaterials used for repairing bone defect caused by osteoporotic fractures and provides a prospect in this field, with the aim to provide a reference for the treatment of osteoporotic fractures.
