Matrix metalloproteinase-3 in patients with systemic lupus erythematosus and its significance in differentiating disease activity from pulmonary infections
10.3760/cma.j.issn.0578-1426.2020.01.010
- VernacularTitle: 系统性红斑狼疮患者血清基质金属蛋白酶-3水平及其在鉴别疾病活动与合并肺部感染的意义
- Author:
Mingyao LI
1
;
Yunqiang BAI
2
;
Yi LIU
1
,
3
Author Information
1. Department of Rheumatology and Immunology, Subsidiary Hospital, Southwestern Medical University, Luzhou, Sichuan Province 646000, China
2. Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China
3. Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China
- Publication Type:Case Reports
- Keywords:
Lupus erythematosus, systemic;
Pulmonary infection;
Matrix metalloproteinase 3;
C-reactive protein
- From:
Chinese Journal of Internal Medicine
2020;59(1):58-61
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of this study is to investigate the matrix metalloproteinase-3 (MMP-3) levels in patients with systemic lupus erythematosus (SLE) and its significance in identifying disease activity and pulmonary infections. A total of 122 SLE patients were enrolled, including 21 with pulmonary infections, 16 with arthritis, 26 with nephritis, 10 with vasculitis, and 23 healthy controls. Serum MMP-3, C-reactive protein (CRP), serum amyloid A (SAA), and haptoglobin (HPT) levels were measured in all subjects. The results showed that the levels of MMP-3 in SLE combined with pulmonary infections [(230.10±44.92) μg/L], arthritis [(140.20±20.76) μg/L], nephritis [(155.40±23.36) μg/L] were higher than those in SLE only [(91.74±10.47) μg/L]. The levels of MMP-3 [(210.30±45.71) μg/L], CRP [(12.11±5.21) mg/L], HPT [(1.57±0.23) g/L] in active SLE combined with pulmonary infections were higher than those inactive SLE without pulmonary infections including MMP-3 [(124.00±15.22) μg/L], CRP [(7.76±2.96) mg/L], HPT [(0.89±0.09) g/L]. The levels of CRP [(10.03±2.70) mg/L], SAA [(89.22±36.77) mg/L] in active SLE with pulmonary infections and CRP[(7.76±2.96) mg/L], SAA [(60.22±19.7) mg/L] in active SLE without pulmonary infections were higher than CRP [(1.90±0.39) mg/L], SAA [(17.60±3.89) mg/L] in stable SLE with pulmonary infections. It suggests that the levels of CRP and SAA are elevated in active SLE with pulmonary infections. Serum MMP-3 in combination with CRP may assist in differentiating from SLE pulmonary infections.
