Clinical Observation of Jiawei Xiaoyaosan in Treating Liver Depression and Spleen Deficiency Type 2 Diabetes with Emotional Disorder
10.13422/j.cnki.syfjx.20190116
- VernacularTitle: 加味逍遥散治疗肝郁脾虚型2型糖尿病伴情绪障碍患者的临床观察
- Author:
Fang-fang LI
1
;
Xue-dong KANG
2
Author Information
1. Gansu University of Chinese Medicine, Lanzhou 730000, China
2. Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730020, China
- Publication Type:Research Article
- Keywords:
Jiawei Xiaoyaosan;
liver depression and spleen deficiency;
type 2 diabetes;
dysthymic disorder
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(2):134-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical efficacy of Jiawei Xiaoyaosan for patients with anxiety and depression in type 2 diabetes with liver depression and spleen deficiency. Method:The 76 eligible patients with anxiety and depression in type 2 diabetes with liver depression and spleen deficiency were randomly divided into two groups:control group (38 cases) and treatment group (38 cases). In control group, the basic medicines metformin sustained-release tablets combined with deanxit were given; based on the treatment in control group, the patients in treatment additionally received Jiawei Xiaoyaosan. The changes of fasting plasma glucose (FPG), 2 hours postprandial blood glucose (2 hPG), haemoglobin A1c (HbA1c), fasting insulin (FINS) and serum insulin levels 30 minutes after glucose intake (30 min INS), Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA) and so on were observed and compared. Result:As compared with those before treatment, the levels of FPG, 2 hPG and HbA1c were decreased significantly (P<0.05), fasting serum insulin levels were significantly decreased (P<0.01), 30 min INS levels were increased (P<0.05); HAMD and HAMA scores were significantly decreased (P<0.05). After treatment, the levels of FPG, 2 hPG and HbA1c in the treatment group were significantly lower than those in control group (P<0.01), and the FINS level in treatment group was lower (P<0.05) while 30 min INS level was higher than those in control group (P<0.05); in addition, the HAMD and HAMA scores in the treatment group were significantly lower than those in control group (P<0.01), but there was no significant difference in adverse reactions between two groups. Conclusion:Jiawei Xiaoyaosan combined with basic medication can significantly reduce depression and anxiety in patients with type 2 diabetes mellitus of liver depression and spleen deficiency, reduce blood glucose, glycosylated hemoglobin, decrease fasting insulin and increase 30 min INS level. The effect may be related to the improvement of anxiety, depression and other adverse emotions in these patients.
