Effect of Method of Regulating Qi to Dissipate Blood Stasis and Phlegm on Cardiac Rehabilitation in Patients with Qi Deficiency and Blood Stasis Type Chronic Heart Failure
10.13422/j.cnki.syfjx.20190343
- VernacularTitle: 理气化痰祛瘀法对慢性心力衰竭气虚血瘀型患者心脏康复的观察
- Author:
Hai-ping MOU
1
;
Ting LIU
1
;
Hong-bo MA
2
Author Information
1. Ji'nan Huaiyin People's Hospital, Ji'nan 250021, China
2. Shandong Provincial Hospital, Ji'nan 250021, China
- Publication Type:Research Article
- Keywords:
chronic heart failure;
Danshenyin;
Xuefu Zhuyutang;
ventricular remodeling;
quality of life;
progress of the disease;
cardiac rehabilitation
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(3):131-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe effect of method of regulating Qi to dissipate blood stasis and phlegm on degree of heart failure, ventricular remodeling, disease progression in patients with Qi deficiency and blood stasis type chronic heart failure (CHF).Method: One hundred and thirty-four patients with CHF were randomly divided into control group (62 cases) and observation group (62 cases) by random number table. The patients in control group got spironolactone tablets, 20 mg/time and qd. Benazepril, 20 mg/time and qd. Bisoprolol, 10 mg/time and qd. And digaoxin tablets if necessary. Based on the treatment in control group, patients in observation group additionally received Danshenyin and Xuefu Zhuyutang, 1 dose/day. The treatment course was 3 months in both groups. Before and after treatment, scores of Lee heart failure score were graded, cardiac function classification of the New York Heart Association (NYHA), 6 mins' walking test (6 MWT), scores of Qi deficiency and blood stasis and Minnesota living with heart failure questionnaire (MLHFQ) were evaluated. Echocardiography, left ventricular ejection fraction (LVEF), Left ventricular end-diastolic diameter (LVEDd), left ventricular end-stolic diameter (LVEDs), interventricular septum thickness at end-diastole (IVSd) and left ventricular myocardial mass index (LVMI) were recorded. Levels of matrix metalloprotein-9 (MMP-9), tissue inhibitor of matrix metalloprotease-1 (TIMP-1), transforming growth factor-β1 (TGF-β1), N-terminal pro-B-type na-triuretic peptide (NT-proBNP), galectin-3 and copeptin were detected.Result: Ridit analysis showed that after treatment, effect on cardiac function in observation group was better than that in control group (P<0.05). Classification of cardiac function of NYHA was lower than that in control group (P<0.05). The LVEDd, LVEDs and LVMI in observation group were all less than those in control group (P<0.05), while LVEF was higher than that in control group (P<0.05). There was no statistically significant difference in IVSd between two groups. Scores of Lee heart failure score, MLHFQ and Qi deficiency and blood stasis in observation group were lower than those in control group, and distance of 6 mins' walking was larger than that in control group (P<0.01). Levels of serum MMP-9, TGF-β1, NT-proBNP, galectin-3 and copeptin in observation group were lower than those in control group, while level of TIMP-1 was higher than that in control group (P<0.01).Conclusion: Based on the routine western medicine treatment, additional Danshenyin and Xuefu Zhuyutang can ameliorate symptoms of heart failure, relieve degree of heart failure, improve exercise tolerance and quality of life, inhibit ventricular remodeling, improve cardiac rehabilitation and delay progress of the disease for the CHF patients with Qi deficiency and blood stasis.
