Clinical Efficacy of Modified Sinisan Combined with Saccharomyces Brasiliensis on Functional Dyspepsia in Children and Its Effect on Serum Cytokines
10.13422/j.cnki.syfjx.20190220
- VernacularTitle: 四逆散加味联合布拉氏酵母菌治疗小儿功能性消化不良的临床疗效及对血清细胞因子的影响
- Author:
Guo-xing FANG
1
;
Jing-chan YAO
2
;
Guo-hua HU
2
;
Lu-ka ZHU
3
;
Yu-rui PAN
2
Author Information
1. Jinhua Maternal and Child Health Hospital, Jinhua 321000, China
2. Jinhua Polytechnic Medical College, Jinhua 321017, China
3. Yiwu Central Hospital, Yiwu 322000, China
- Publication Type:Research Article
- Keywords:
functional dyspepsia;
child;
saccharomyces boulardi;
modified Sinisan (Qizhi Weitong granule);
cytokine;
gastrointestinal hormones
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(3):120-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To discuss the clinical efficacy of modified Sinisan (Qizhi Weitong granule) and saccharomyces boulardi in treating functional dyspepsia (FD) in children, and its effect on changes in serum cytokine and gastrointestinal hormones.Method: Totally 156 cases were divided into control group (78 cases) and observation group (78 cases). The control group was treated with saccharomyces boulardi, 0.25 g, po, bid, after meal. In addition to the therapy of control group, the observation group was also given modified Sinisan (Qizhi Weitong granule), 2.5 g, po, tid, 30 minutes before meal. Four weeks was a course of treatment. Then the clinical efficacy, the time of symptom improvement and the change of serum cytokine and gastrointestinal hormones were observed.Result: The total effective rate of observation group (96.15%) was higher than that of control group (82.05%), with statistical difference (P<0.01). The serum levels of interleukin-10 (IL-10), interferon-γ(IFN-γ), tumor necrosis factor-α(TNF-α), plasma motilin(MTL) and Leptin of both groups had no statistical difference before treatment. After treatment, the serum levels of IL-10, MTL of both group were increased, while the serum levels of IFN-γ, TNF-α, Leptin of both group were decreased. However, the decreasing range and the increasing range of observation group were statistically obvious than those of control group (P<0.01). After the 6-month follow-up, the recurrent rate (6.67%) of the observation group was statistically lower than that of control group (18.75%).Conclusion: Modified Sinisan(Qizhi Weitong granule) combined with saccharomyces boulardi have an obvious clinical efficacy in treating child's FD, with a low recurrence. The mechanism may be correlated with the effect of integrated Chinese and Western medicines in regulating serum cytokine and gastrointestinal hormones levels.
