Effect and Mechanism of Modified Danzhi Xiaoyaosan in Treating Post-stroke Depression
10.13422/j.cnki.syfjx.20190329
- VernacularTitle: 丹栀逍遥散加减治疗卒中后抑郁的疗效及作用机制
- Author:
Li-min JIANG
1
;
Xiang-zhe LIU
1
Author Information
1. The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
- Publication Type:Research Article
- Keywords:
modified Danzhi Xiaoyaosan;
liver soothing method;
post-stroke depression;
neurotransmitter;
inflammatory factor;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(3):108-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the clinical efficiency of the liver soothing method(modified Danzhi Xiaoyaosan) in the treatment of post-stroke depression(PSD), and explore its mechanism.Method: A total of 148 patients with PSD were randomly divided into study group and control group, with 74 cases in each group. Control group received Escitalopram Oxalate, 10 mg·d-1. Study group received Shugan granule 3 g, twice a day, in addition to the therapy of control group. One course of treatment of 4 weeks. Hamilton depression scale (HAMD) score, neurotransmitter power, 5-hydroxytryptamine(5-HT), noradrenalin(NE) levels and inflammatory factors were compared between the two groups.Result: The clinical efficacy of study group was significantly better than that of control group(Z=2.97, P<0.05), and the total effective rate in study group was significantly higher than that of control group (87.84%,74.32%, χ2=4.40, P<0.05). HAMD scores in both groups decreased in the process of treatment (P<0.05). HAMD score in study group was reduced more significantly than that in control group (P<0.05). The overall levels of HAMD score in study group was significantly lower than that in control group (P<0.05). The power and overall levels of 6 kinds of neurotransmitters in both group were increased in the process of treatment (P<0.05). The power of 6 kinds of neurotransmitters in study group were increased more significantly than that in control group (P<0.05). The levels of 5-HT and NE in both groups increased in the process of treatment (P<0.05). The overall levels of 5-HT and NE in study group were significantly higher than those in control group (P<0.05). Tumor necrosis factor-α(TNF-α), interleukin-1 beta(IL-1β) and interleukin-6(IL-6) levels in both groups decreased in the process of treatment (P<0.05). TNF-α, IL-1β and IL-6 levels in study group were decreased more significantly than those in control group (P<0.05).Conclusion: Modified Danzhi Xiaoyaosan combined with traditional antidepressants has a more significant curative effect in the treatment of PSD. The mechanism may be related to the inhibition of the expressions of inflammatory factors. Further studies shall be conducted.
