Relationship between PET/CT metabolic parameters and pathological features and prognosis in ESCC patients with intramural gastric metastasis
10.3872/j.issn.1007-385x.2019.05.008
- VernacularTitle:食管鳞癌胃壁内转移患者PET/CT代谢参数与病理特征及预后的关系
- Author:
GAO Taotao
1
;
XU Meiqing
2
Author Information
1. Clinical College, Anhui Provincial Hospital Affiliated to Anhui Medical University
2. Department of Thoracic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University
- Publication Type:Journal Article
- Keywords:
esophageal squamous cell carcinoma (ESCC);
intramural gastric metastasis (IGM);
positron emission tomography and computed tomography (PET/CT);
pathological characteristics;
prognosis
- From:
Chinese Journal of Cancer Biotherapy
2019;26(5):530-535
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between PET/CT metabolic parameters and pathological features and prognosis in esophageal squamous cell carcinoma (ESCC) patients with intramural gastric metastasis (IGM). Methods: Totally 86 cases of ESCC IGM patients treated in Anhui Provincial Hospital Affiliated to Anhui Medical University from January 2008 to December 2014 were selected for this study. The patients received the imaging examination by positron emission tomography and computed tomography (PET/CT). The metabolic parameters including maximum standard uptake value (SUVmax), metabolic tumor volume (MTV), PET tumor length (PTL) and mean standard uptake value (SUVmean) were examined to calculate the total lesion glycolysis (TLG). The survival of the patients during 5-year follow-up was recorded, and the relationship between metabolic parameters and clinical pathological features and prognosis was analyzed. Results: SUVmax and SUVmean of IGM patients were related to the diameter of the primary tumor (all P<0.05); MTV was associated with the tumor diameter, lymph node metastasis, and TNM staging (all P<0.05); TLG was associated with the tumor diameter, lymph node metastasis, TNM stage, and tissue differentiation (all P<0.05). During the 5-year follow-up, 6 patients were lost to follow-up, 36 patients died and 44 patients survived; SUVmax, MTV, TLG, PTL, SUVmean, and TNM staging were predictors for patients’prognosis (all P<0.05); MTV, TLG, PTL, SUVmean, and TNM staging were risk factors for prognosis (all P< 0.05). Conclusion: The metabolic parameters including SUVmax, MTV, TLG, PTL and SUVmean in ESCC patients with IGM are related to the pathological characteristics of patients; moreover, MTV, TLG, PTL, SUVmean and TNM staging are risk factors for prognosis; so, PET/CT examination has certain clinical value for the prognosis assessment in ESCC patients with IGM.
- Full text:20190508.pdf
