Research progress of microglia in eye disease
10.3980/j.issn.1672-5123.2020.3.14
- VernacularTitle:小胶质细胞在眼病中的研究进展
- Author:
Ling Cui
1
,
2
Author Information
1. Department of Ophthalmology, People'
2. s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, ChinaCo-first authors: Ling Cui and Guang-Yi Huang.
- Publication Type:Journal Article
- Keywords:
microglia;
optic nerve injury;
diabetic retinopathy;
glaucoma;
targeted therapy;
basic research
- From:
International Eye Science
2020;20(3):472-476
- CountryChina
- Language:Chinese
-
Abstract:
Microglia are the resident macrophages of the central nervous system(CNS). Microglia constantly monitor the pathological changes of the surrounding microenvironment. Activated microglia play key roles in tissue protection and injury under the stimulation of various injury factors. Abnormal activation of microglia mediates retinal inflammation and aggravates the original ophthalmic diseases. Our growing understanding of the mechanisms of the interaction between microglia and retinal cells is identifying potential cellular and molecular targets for therapeutic interventions that may be apply to optic nerve injury, diabetic retinopathy, glaucoma and other diseases in the future. In this review, potential links between ophthalmic diseases and microglial activity will be explored.
