Progress of the relationship between iron metabolism and solid tumors
10.3760/cma.j.issn.1006-9801.2019.09.015
- VernacularTitle: 铁代谢与实体肿瘤关系的研究进展
- Author:
Zhihui GAO
1
;
Houbao LIU
Author Information
1. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
- Publication Type:Review
- Keywords:
Iron metabolism disorders;
Ferroptosis;
Neoplasms
- From:
Cancer Research and Clinic
2019;31(9):637-640
- CountryChina
- Language:Chinese
-
Abstract:
Iron is an important nutrient element which is involved in a variety of physiological processes. The potential toxicity of excess iron requires that cells should evolve a robust, tightly regulated mechanism for maintaining iron homeostasis. At the same time, iron plays an indispensable role in the process of tumorigenesis and progression. The mechanism involved in iron homeostasis can make changes to adapt to its metabolic level and to maintain the activity of the tumor cells. This paper reviews iron metabolism and its role in the maintaining of iron homeostasis, as well as the importance of iron metabolism in solid cancers.
