Comparison of clinical effects of Qinghuang powder, low-intensity chemotherapy and alternated treatment on elderly patients with acute myeloid leukemia progressed from myelodysplastic syndromes
10.3760/cma.j.issn.1009-9921.2019.09.003
- VernacularTitle: 青黄散、低强度化疗以及二者交替治疗老年人骨髓增生异常综合征转化的急性髓系白血病临床效果比较
- Author:
Zhuo CHEN
1
;
Teng FAN
2
;
Haiyan XIAO
1
;
Richeng QUAN
1
;
Weiyi LIU
1
;
Xudong TANG
1
;
Yan LYU
1
;
Chi LIU
1
;
Liu LI
1
;
Xiaomei HU
1
Author Information
1. Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
2. Graduate School, China Academy of Chinese Medical Sciences, Beijing 100700, China
- Publication Type:Journal Article
- Keywords:
Myelodysplastic syndromes;
Leukemia, myeloid, acute;
Aged;
Qinghuang powder;
Low-intensity chemotherapy
- From:
Journal of Leukemia & Lymphoma
2019;28(9):523-526
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effects of Qinghuang powder, low-intensity chemotherapy and Qinghuang powder alternated with low-intensity chemotherapy in the treatment of elderly acute myeloid leukemia patients progressed from myelodysplastic syndromes (MDS-AML).
Methods:A total of 32 elderly patients with MDS-AML treated in Xiyuan Hospital, China Academy of Chinese Medical Sciences from January 2014 to December 2017 were retrospectively analyzed. Of them, 12 patients received Qinghuang powder (Qinghuang powder group), 6 patients received Qinghuang powder alternated with low-intensity chemotherapy (alternating group), and 14 patients received low-intensity chemotherapy (low-intensity chemotherapy group), based on the real world of patient's voluntary choice of treatment. The efficacy and adverse reactions in the 3 groups were observed.
Results:The overall response number of Qinghuang powder, alternating, and low-intensity chemotherapy groups were 2, 2 and 4 cases, respectively, there was no significant difference among the 3 groups (P > 0.05). The median overall survival time of 3 groups were 14, 12 and 8 months, respectively, there was no significant difference among the 3 groups (P > 0.05). Two cases in Qinghuang powder group presented with gastrointestinal reactions; 3 cases in alternating group with myelosuppression, 2 cases with liver function damage, and 2 cases with gastrointestinal reaction; 11 cases in low-intensity chemotherapy group presented with bone marrow suppression, 3 cases with liver function damage, 7 cases with gastrointestinal reactions, and 2 cases with myocardial enzyme changes. The incidences of myelosuppression, liver function damage and myocardial enzyme changes in Qinghuang powder group were lower than those in the alternating group and low-intensity chemotherapy group.
Conclusion:The efficacy of Qinghuang powder or Qinghuang powder alternated with low-intensity chemotherapy for the treatment of elderly MDS-AML is not worse than the low-intensity chemotherapy, furthermore Qinghuang powder or Qinghuang powder alternated with low-intensity chemotherapy has fewer adverse reactions and better tolerance.
