Correlations of serum uric acid with outcomes and symptomatic intracranial hemorrhage after intravenous thrombolysis bridging with intravascular mechanical thrombectomy in patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2019.09.003
- VernacularTitle: 血清尿酸与缺血性卒中患者静脉溶栓桥接血管内机械血栓切除后的转归和有症状颅内出血的相关性
- Author:
Qing GAO
1
;
Nihong CHEN
1
;
Fuping JIANG
2
;
Junshan ZHOU
1
Author Information
1. Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
2. Department of Geriatrics, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain ischemia;
Thrombolytic therapy;
Thrombectomy;
Uric acid;
Treatment outcome;
Intracranial hemorrhages
- From:
International Journal of Cerebrovascular Diseases
2019;27(9):651-655
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlations of serum uric acid with outcomes and symptomatic intracranial hemorrhage (sICH) after intravascular mechanical thrombectomy bridged with intravenous thrombolysis in patients with ischemic stroke.
Methods:From January 2015 to January 2019, patients with acute ischemic stroke admitted to Nanjing First Hospital, Nanjing Medical University and underwent intravascular mechanical thrombectomy bridged with intravenous thrombolysis were analyzed retrospectively. Demographic characteristics, vascular risk factors, laboratory findings, National Institutes of Health Stroke Scale (NIHSS) scores, onset to treatment time, and whether sICH occurred were recorded. The modified Rankin Scale was used to evaluate the outcomes at 90 d after onset, and 0 to 2 was defined as good outcome. Multivariate logistic regression models were used to determine the independent factors for outcomes and sICH.
Results:A total of 144 patients were included, 54 (37.5%) had a good outcome, 90 (62.5%) had a poor outcome (including 28 deaths), and 29 (20.1%) had sICH. Serum uric acid was significantly higher in the good outcome group than in the poor outcome group (P<0.05). Serum uric acid was significantly higher in the non-sICH group than in the sICH group (P<0.05). Multivariate logistic regression analysis showed that higher serum uric acid were the independent protective factors of good outcome (odds ratio 0.82, 95% confidence interval 0.66-0.93; P<0.001) and sICH (odds ratio 0.97, 95% confidence interval 0.93-0.99; P=0.004).
Conclusion:High serum uric acid level is independently associated with good outcome after intravascular mechanical thrombectomybridged with intravenous thrombolysis in patients with acute ischemic stroke.
