Role of hypoxia-inducible factor-1a in ischemia/reperfusion injury of donor kidney during kidney transplantation
10.3760/cma.j.issn.1673-4203.2019.09.015
- VernacularTitle: 缺氧诱导因子-1α在肾移植供肾缺血/再灌注损伤中的作用
- Author:
Yuanming HAN
1
;
Shuang GUO
2
;
Xuanpeng LI
2
;
Li YANG
2
Author Information
1. Department of Urology, the First People′s Hospital of Lanzhou City, Lanzhou 730050, China
2. Lanzhou University Institute of Urology, Department of Urology, Lanzhou University Second Hospital, Gansu Nephron-Urological Clinical Center, Gansu Provincial Key Laboratory of Urological System Diseases, Lanzhou 730030, China
- Publication Type:Review
- Keywords:
Hypoxia-inducible factor 1, alpha subunit;
Kidney transplantation;
Ischemia;
Reperfusion injury
- From:
International Journal of Surgery
2019;46(9):634-639
- CountryChina
- Language:Chinese
-
Abstract:
In the process of kidney acquisition and transplantation, the donor kidney undergoes hypoxia, ischemia and reperfusion, which inevitably leads to ischemia/reperfusion (I/R) injury of the donor kidney. Hypoxia-inducible factor-1α(HIF-1α) is a ubiquitous oxygen-sensitive transcription factor. It can be activated rapidly during I/R injury. Then preventing and reducing the I/R injury of donor kidney during kidney transplantation by mediating the adaptation of donor kidney to hypoxic stress through direct or indirect ways, and participating in the repair of injury, thereby improving the effect of kidney transplantation. This review describes the evidence of the role of HIF-1α in I/R injury of donor kidney during kidney transplantation, and provides a theoretical basis for further research.
